{
  "annotation_id": "93f45504-f4f1-44da-a5f3-2699db927699",
  "date_created": "2026-03-02T18:01:28.469000Z",
  "date_modified": "2026-03-02T18:01:28.469000Z",
  "file_hash": "1c0e5abaa4267e04716f146f9324c288b454c6b2f2a8f6a4883612b585175821",
  "private": false,
  "record": {
    "abstract": "How DNA repair enzymes find the relatively rare sites of damage is not known\nin great detail. Recent experiments and molecular data suggest that the\nindividual repair enzymes do not work independently of each other, but rather\ninteract with each other through currents exchanged along DNA. A damaged site\nin DNA hinders this exchange and this makes it possible to quickly free up\nresources from error free stretches of DNA. Here the size of the speedup gained\nfrom this current exchange mechanism is calculated and the characteristic\nlength and time scales are identified. In particular for Escherichia coli we\nestimate the speedup to be 50000/N, where N is the number of repair enzymes\nparticipating in the current exchange mechanism. Even though N is not exactly\nknown a speedup of order 10 is not entirely unreasonable. Furthermore upon over\nexpression of repair enzymes the detection time only varies as one over the\nsquareroot of N and not as 1/N. This behavior is of interest in assessing the\nimpact of stress full and radioactive environments on individual cell mutation\nrates.",
    "arxiv_id": "q-bio/0311033",
    "authors": [
      "Kasper Astrup Eriksen"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "title": "Localization of DNA damage by current exchanging repair enzymes: effects   of cooperativity on detection time",
    "url": "https://arxiv.org/abs/q-bio/0311033"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9518d9ac-7ece-4772-88e1-fa0dd7ae4874",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}