{
  "annotation_id": "937c2eac-160e-4bb4-8ab0-b353101130ad",
  "date_created": "2026-03-02T18:01:31.348000Z",
  "date_modified": "2026-03-02T18:01:31.348000Z",
  "file_hash": "415350b38c169c3b0039cbb2b1a58af711fc7d6dec3d4fe88594291d55c5d650",
  "private": false,
  "record": {
    "abstract": "As cell proliferation is limited due to the loss of telomere repeats in DNA\nof normal somatic cells during division, telomere attrition can possibly play\nan important role in determining the maximum life span of organisms as well as\ncontribute to the process of biological ageing. With computer simulations of\ncell culture development in organisms, which consist of tissues of normal\nsomatic cells with finite growth, we otain an increase of life span and life\nexpectancy for longer telomeric DNA in the zygote. By additionally considering\na two-mutation model for carcinogenesis and indefinite proliferation by the\nactivation of telomerase, we demonstrate that the risk of dying due to cancer\ncan outweigh the positive effect of longer telomeres on the longevity.",
    "arxiv_id": "q-bio/0507006",
    "authors": [
      "Michael Masa",
      "Stanislaw Cebrat",
      "Dietrich Stauffer"
    ],
    "categories": [
      "q-bio.PE"
    ],
    "doi": "10.1016/j.physa.2005.08.043",
    "title": "Does telomere elongation lead to a longer lifespan if cancer is   considered?",
    "url": "https://arxiv.org/abs/q-bio/0507006"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "3f7cefc2-6d04-4b4e-9001-5ec93cdc740b",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}