{
  "annotation_id": "935909e4-bd1c-420d-99c3-8500ac152496",
  "date_created": "2026-03-02T18:01:34.889000Z",
  "date_modified": "2026-03-02T18:01:34.889000Z",
  "file_hash": "08900f9d1f1aca186585f68c2bf0523658e4b2c520c34903f59ef53b5b95070a",
  "private": false,
  "record": {
    "abstract": "Among features of real immune responses which occur when antigens invade a\nbody,there are two remarkable features. One is that the amount of antibodies\nproduced in the secondary invasion by the same antigens is more than 10 times\nlarger than that in the primary invasion. The other is that more effective\nantibodies which can neutralize the antigens more quickly are produced by\nsomatic hypermutation during the immune response. This phenomenon is named as\n\u0027affinity maturation\u0027. In this paper, we try to reproduce these features by\ndynamical system models and present possible factors to realize them. Further,\nwe present a model in which the memory of the invasion by antigens is realized\nwithout immune memory cells.",
    "arxiv_id": "q-bio/0602007",
    "authors": [
      "Mika Yoshida",
      "Kinji Fuchikami",
      "Tatsuya Uezu"
    ],
    "categories": [
      "q-bio.PE"
    ],
    "title": "Realization of features of immune response by dynamical system models   and a possible mechanism of memory of antigen invasion",
    "url": "https://arxiv.org/abs/q-bio/0602007"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "7ef32159-95a0-4916-8cc2-d3c882b098bc",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}