dorsal/arxiv
View SchemaGenetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model
| Authors | Sandra Kanani, Alain Pumir, Valentine Krinsky |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511015 |
| URL | https://arxiv.org/abs/q-bio/0511015 |
Abstract
Artificial biological pacemakers were developed and tested in canine ventricles. Next steps will require obtaining oscillations sensitive to external regulations, and robust with respect to long term drifts of expression levels of pacemaker currents and gap junctions. We introduce mathematical models intended to be used in parallel with the experiments. The models describe human mesenchymal stem cells ({\it hMSC}) transfected with HCN2 genes and connected to myocytes. They are intended to mimic experiments with oscillation induction in a cell pair, in cell culture and in the cardiac tissue. We give examples of oscillations in a cell pair, in a 1 dim cell culture, and oscillation dependence on number of pacemaker channels per cell and number of gap junctions. The models permit to mimic experiments with levels of gene expressions not achieved yet, and to predict if the work to achieve this levels will significantly increase the quality of oscillations. This give arguments for selecting the directions of the experimental work.
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"date_created": "2026-03-02T18:01:35.446000Z",
"date_modified": "2026-03-02T18:01:35.446000Z",
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"abstract": "Artificial biological pacemakers were developed and tested in canine\nventricles. Next steps will require obtaining oscillations sensitive to\nexternal regulations, and robust with respect to long term drifts of expression\nlevels of pacemaker currents and gap junctions. We introduce mathematical\nmodels intended to be used in parallel with the experiments.\n The models describe human mesenchymal stem cells ({\\it hMSC}) transfected\nwith HCN2 genes and connected to myocytes. They are intended to mimic\nexperiments with oscillation induction in a cell pair, in cell culture and in\nthe cardiac tissue. We give examples of oscillations in a cell pair, in a 1 dim\ncell culture, and oscillation dependence on number of pacemaker channels per\ncell and number of gap junctions. The models permit to mimic experiments with\nlevels of gene expressions not achieved yet, and to predict if the work to\nachieve this levels will significantly increase the quality of oscillations.\nThis give arguments for selecting the directions of the experimental work.",
"arxiv_id": "q-bio/0511015",
"authors": [
"Sandra Kanani",
"Alain Pumir",
"Valentine Krinsky"
],
"categories": [
"q-bio.CB"
],
"title": "Genetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model",
"url": "https://arxiv.org/abs/q-bio/0511015"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "7bf353c2-d177-4e84-ab6e-b17ec932da44",
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"type": "Model",
"variant": "snapshot-2026-03-01",
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