dorsal/arxiv
View SchemaSignal detection, modularity and the correlation between extrinsic and intrinsic noise in biochemical networks
| Authors | Sorin Tanase-Nicola, Patrick B. Warren, Pieter Rein ten Wolde |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0508027 |
| URL | https://arxiv.org/abs/q-bio/0508027 |
| DOI | 10.1103/PhysRevLett.97.068102 |
Abstract
Understanding cell function requires an accurate description of how noise is transmitted through biochemical networks. We present an analytical result for the power spectrum of the output signal of a biochemical network that takes into account the correlations between the noise in the input signal (the extrinsic noise) and the noise in the reactions that constitute the network (the intrinsic noise). These correlations arise from the fact that the reactions by which biochemical signals are detected necessarily affect the signaling molecules and the detection components of the network simultaneously. We show that anti-correlation between the extrinsic and intrinsic noise enhances the robustness of zero-order ultrasensitive networks to biochemical noise. We discuss the consequences of the correlation between extrinsic and intrinsic noise for a modular description of noise transmission through large biochemical networks in the context of the mitogen-activated protein kinase cascade.
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"abstract": "Understanding cell function requires an accurate description of how noise is\ntransmitted through biochemical networks. We present an analytical result for\nthe power spectrum of the output signal of a biochemical network that takes\ninto account the correlations between the noise in the input signal (the\nextrinsic noise) and the noise in the reactions that constitute the network\n(the intrinsic noise). These correlations arise from the fact that the\nreactions by which biochemical signals are detected necessarily affect the\nsignaling molecules and the detection components of the network simultaneously.\nWe show that anti-correlation between the extrinsic and intrinsic noise\nenhances the robustness of zero-order ultrasensitive networks to biochemical\nnoise. We discuss the consequences of the correlation between extrinsic and\nintrinsic noise for a modular description of noise transmission through large\nbiochemical networks in the context of the mitogen-activated protein kinase\ncascade.",
"arxiv_id": "q-bio/0508027",
"authors": [
"Sorin Tanase-Nicola",
"Patrick B. Warren",
"Pieter Rein ten Wolde"
],
"categories": [
"q-bio.MN"
],
"doi": "10.1103/PhysRevLett.97.068102",
"title": "Signal detection, modularity and the correlation between extrinsic and intrinsic noise in biochemical networks",
"url": "https://arxiv.org/abs/q-bio/0508027"
},
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