dorsal/arxiv
View SchemaJanus Polymeric Giant Vesicles on Demand: A Predictive Phase Separation Approach for Efficient Formation
| Authors | Eloise Equy, Emmanuel Ibarboure, Eric Grelet, Sebastien Lecommandoux |
|---|---|
| Categories | |
| ArXiv ID | 2601.07409vv1 |
| URL | https://arxiv.org/abs/2601.07409 |
| DOI | 10.1021/jacs.4c18003 |
| Journal | J. Am. Chem. Soc 147, 9727 (2025) |
| License | http://creativecommons.org/licenses/by/4.0/ |
Abstract
Janus particles, with their intrinsic asymmetry, are attracting major interest in various applications, including emulsion stabilization, micro/nanomotors, imaging, and drug delivery. In this context, Janus polymersomes are particularly attractive for synthetic cell development and drug delivery systems. While they can be achieved by inducing a phase separation within their membrane, their fabrication method remains largely empirical. Here, we propose a rational approach, using Flory-Huggins theory, to predict the self-assembly of amphiphilic block copolymers into asymmetric Janus polymersomes. Our predictions are experimentally validated by forming highly stable Janus giant unilamellar vesicles (JGUVs) with a remarkable yield exceeding 90% obtained from electroformation of various biocompatible block copolymers. We also present a general phase diagram correlating mixing energy with polymersome morphology, offering a valuable tool for JGUV design. These polymersomes can be extruded to achieve quasi-monodisperse vesicles while maintaining their Janus-like morphology, paving the way for their asymmetric functionalization and use as active carriers.
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"abstract": "Janus particles, with their intrinsic asymmetry, are attracting major interest in various applications, including emulsion stabilization, micro/nanomotors, imaging, and drug delivery. In this context, Janus polymersomes are particularly attractive for synthetic cell development and drug delivery systems. While they can be achieved by inducing a phase separation within their membrane, their fabrication method remains largely empirical. Here, we propose a rational approach, using Flory-Huggins theory, to predict the self-assembly of amphiphilic block copolymers into asymmetric Janus polymersomes. Our predictions are experimentally validated by forming highly stable Janus giant unilamellar vesicles (JGUVs) with a remarkable yield exceeding 90% obtained from electroformation of various biocompatible block copolymers. We also present a general phase diagram correlating mixing energy with polymersome morphology, offering a valuable tool for JGUV design. These polymersomes can be extruded to achieve quasi-monodisperse vesicles while maintaining their Janus-like morphology, paving the way for their asymmetric functionalization and use as active carriers.",
"arxiv_id": "2601.07409",
"authors": [
"Eloise Equy",
"Emmanuel Ibarboure",
"Eric Grelet",
"Sebastien Lecommandoux"
],
"categories": [
"cond-mat.soft",
"physics.chem-ph"
],
"doi": "10.1021/jacs.4c18003",
"journal_ref": "J. Am. Chem. Soc 147, 9727 (2025)",
"license": "http://creativecommons.org/licenses/by/4.0/",
"title": "Janus Polymeric Giant Vesicles on Demand: A Predictive Phase Separation Approach for Efficient Formation",
"url": "https://arxiv.org/abs/2601.07409",
"version": "v1"
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