dorsal/arxiv
View SchemaIntra-cellular transport by single-headed kinesin KIF1A: effects of single-motor mechano-chemistry and steric interactions
| Authors | Philip Greulich, Ashok Garai, Katsuhiro Nishinari, Andreas Schadschneider, Debashish Chowdhury |
|---|---|
| Categories | |
| ArXiv ID | physics/0612054 |
| URL | https://arxiv.org/abs/physics/0612054 |
| DOI | 10.1103/PhysRevE.75.041905 |
| Journal | Physical Review E, vol.75, 041905 (2007). |
Abstract
In eukaryotic cells, many motor proteins can move simultaneously on a single microtubule track. This leads to interesting collective phenomena like jamming. Recently we reported ({\it Phys. Rev. Lett. {\bf 95}, 118101 (2005)}) a lattice-gas model which describes traffic of unconventional (single-headed) kinesins KIF1A. Here we generalize this model, introducing a novel interaction parameter $c$, to account for an interesting mechano-chemical process which has not been considered in any earlier model. We have been able to extract all the parameters of the model, except $c$, from experimentally measured quantities. In contrast to earlier models of intra-cellular molecular motor traffic, our model assigns distinct ``chemical'' (or, conformational) states to each kinesin to account for the hydrolysis of ATP, the chemical fuel of the motor. Our model makes experimentally testable theoretical predictions. We determine the phase diagram of the model in planes spanned by experimentally controllable parameters, namely, the concentrations of kinesins and ATP. Furthermore, the phase-separated regime is studied in some detail using analytical methods and simulations to determine e.g. the position of shocks. Comparison of our theoretical predictions with experimental results is expected to elucidate the nature of the mechano-chemical process captured by the parameter $c$.
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"abstract": "In eukaryotic cells, many motor proteins can move simultaneously on a single\nmicrotubule track. This leads to interesting collective phenomena like jamming.\nRecently we reported ({\\it Phys. Rev. Lett. {\\bf 95}, 118101 (2005)}) a\nlattice-gas model which describes traffic of unconventional (single-headed)\nkinesins KIF1A. Here we generalize this model, introducing a novel interaction\nparameter $c$, to account for an interesting mechano-chemical process which has\nnot been considered in any earlier model. We have been able to extract all the\nparameters of the model, except $c$, from experimentally measured quantities.\nIn contrast to earlier models of intra-cellular molecular motor traffic, our\nmodel assigns distinct ``chemical\u0027\u0027 (or, conformational) states to each kinesin\nto account for the hydrolysis of ATP, the chemical fuel of the motor. Our model\nmakes experimentally testable theoretical predictions. We determine the phase\ndiagram of the model in planes spanned by experimentally controllable\nparameters, namely, the concentrations of kinesins and ATP. Furthermore, the\nphase-separated regime is studied in some detail using analytical methods and\nsimulations to determine e.g. the position of shocks. Comparison of our\ntheoretical predictions with experimental results is expected to elucidate the\nnature of the mechano-chemical process captured by the parameter $c$.",
"arxiv_id": "physics/0612054",
"authors": [
"Philip Greulich",
"Ashok Garai",
"Katsuhiro Nishinari",
"Andreas Schadschneider",
"Debashish Chowdhury"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech",
"q-bio.SC"
],
"doi": "10.1103/PhysRevE.75.041905",
"journal_ref": "Physical Review E, vol.75, 041905 (2007).",
"title": "Intra-cellular transport by single-headed kinesin KIF1A: effects of single-motor mechano-chemistry and steric interactions",
"url": "https://arxiv.org/abs/physics/0612054"
},
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