dorsal/arxiv
View SchemaStochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
| Authors | Leor S. Weinberger, John C. Burnett, Jared E. Toettcher, Adam P. Arkin, David V. Schaffer |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0608002 |
| URL | https://arxiv.org/abs/q-bio/0608002 |
| Journal | Cell. 2005 Jul 29;122(2):169-82 |
Abstract
Stochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, Weinberger et al. (2005) take an integrated computational-experimental approach to study the Tat transactivation feedback loop in HIV-1 and show that fluctuations in a key regulator, Tat, can result in a phenotypic bifurcation. This phenomenon is observed in an isogenic population where individual cells display two distinct expression states corresponding to latent and productive infection by HIV-1. These findings demonstrate the importance of stochastic gene expression in molecular "decision-making."
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"abstract": "Stochastic gene expression has been implicated in a variety of cellular\nprocesses, including cell differentiation and disease. In this issue of Cell,\nWeinberger et al. (2005) take an integrated computational-experimental approach\nto study the Tat transactivation feedback loop in HIV-1 and show that\nfluctuations in a key regulator, Tat, can result in a phenotypic bifurcation.\nThis phenomenon is observed in an isogenic population where individual cells\ndisplay two distinct expression states corresponding to latent and productive\ninfection by HIV-1. These findings demonstrate the importance of stochastic\ngene expression in molecular \"decision-making.\"",
"arxiv_id": "q-bio/0608002",
"authors": [
"Leor S. Weinberger",
"John C. Burnett",
"Jared E. Toettcher",
"Adam P. Arkin",
"David V. Schaffer"
],
"categories": [
"q-bio.MN",
"cond-mat.soft",
"physics.bio-ph",
"q-bio.CB"
],
"journal_ref": "Cell. 2005 Jul 29;122(2):169-82",
"title": "Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity",
"url": "https://arxiv.org/abs/q-bio/0608002"
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