dorsal/arxiv
View SchemaA continuous model for cell sorting
| Authors | Mathieu Emily, Olivier Francois |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0605035 |
| URL | https://arxiv.org/abs/q-bio/0605035 |
Abstract
The differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue. In this study we introduce a stochastic model supporting the DAH, that can be seen as a continuous version of a discrete model of Graner and Glazier. Our approach is based on the mathematical framework of Gibbsian marked point processes. We provide a Markov chain Monte Carlo algorithm that can reproduce classical biological patterns, and we propose an estimation procedure for a parameter that quantifies the strength of adhesion between cells. This procedure is tested through simulations.
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"abstract": "The differential Adhesion Hypothesis (DAH) is a theory of the organization of\ncells within a tissue. In this study we introduce a stochastic model supporting\nthe DAH, that can be seen as a continuous version of a discrete model of Graner\nand Glazier. Our approach is based on the mathematical framework of Gibbsian\nmarked point processes. We provide a Markov chain Monte Carlo algorithm that\ncan reproduce classical biological patterns, and we propose an estimation\nprocedure for a parameter that quantifies the strength of adhesion between\ncells. This procedure is tested through simulations.",
"arxiv_id": "q-bio/0605035",
"authors": [
"Mathieu Emily",
"Olivier Francois"
],
"categories": [
"q-bio.TO"
],
"title": "A continuous model for cell sorting",
"url": "https://arxiv.org/abs/q-bio/0605035"
},
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