{
  "annotation_id": "8ec90af1-fc34-43a1-a5eb-b261d88426dc",
  "date_created": "2026-03-02T18:01:31.934000Z",
  "date_modified": "2026-03-02T18:01:31.934000Z",
  "file_hash": "b97aa9cc3193345f8665747db98c083c1eb6fb34477393054049c88630a13cd2",
  "private": false,
  "record": {
    "abstract": "Signal transduction pathways are largely conserved throughout the animal\nkingdom. The repertoire of pathways is limited and each pathway is used in\ndifferent intercellular signaling events during the development of a given\nanimal. For example, Wnt signaling is recruited, sometimes redundantly with\nother molecular pathways, in four cell specification events during\nCaenorhabditis elegans vulva development, including the activation of vulval\ndifferentiation. Strikingly, a recent study finds that Wnts act to repress\nvulval differentiation in the nematode Pristionchus pacificus, demonstrating\nevolutionary flexibility in the use of intercellular signaling pathways.",
    "arxiv_id": "q-bio/0508005",
    "authors": [
      "Marie-Anne F\u00e9lix"
    ],
    "categories": [
      "q-bio.PE",
      "q-bio.MN"
    ],
    "doi": "10.1002/bies.20275",
    "journal_ref": "BioEssays 27 (2005) 765-769",
    "title": "An inversion in the wiring of an intercellular signal: evolution of Wnt   signaling in the nematode vulva",
    "url": "https://arxiv.org/abs/q-bio/0508005"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "550e7827-0504-44f8-ab3c-5c07a174c816",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}