dorsal/arxiv
View SchemaAn inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva
| Authors | Marie-Anne Félix |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0508005 |
| URL | https://arxiv.org/abs/q-bio/0508005 |
| DOI | 10.1002/bies.20275 |
| Journal | BioEssays 27 (2005) 765-769 |
Abstract
Signal transduction pathways are largely conserved throughout the animal kingdom. The repertoire of pathways is limited and each pathway is used in different intercellular signaling events during the development of a given animal. For example, Wnt signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation. Strikingly, a recent study finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus, demonstrating evolutionary flexibility in the use of intercellular signaling pathways.
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"abstract": "Signal transduction pathways are largely conserved throughout the animal\nkingdom. The repertoire of pathways is limited and each pathway is used in\ndifferent intercellular signaling events during the development of a given\nanimal. For example, Wnt signaling is recruited, sometimes redundantly with\nother molecular pathways, in four cell specification events during\nCaenorhabditis elegans vulva development, including the activation of vulval\ndifferentiation. Strikingly, a recent study finds that Wnts act to repress\nvulval differentiation in the nematode Pristionchus pacificus, demonstrating\nevolutionary flexibility in the use of intercellular signaling pathways.",
"arxiv_id": "q-bio/0508005",
"authors": [
"Marie-Anne F\u00e9lix"
],
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"q-bio.PE",
"q-bio.MN"
],
"doi": "10.1002/bies.20275",
"journal_ref": "BioEssays 27 (2005) 765-769",
"title": "An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva",
"url": "https://arxiv.org/abs/q-bio/0508005"
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