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MARKETING COMMUNICATION | Factsheet | 30 September 2026
J P M o r g a n F und s T he m a t i c s -
G e ne t i c T he r a p i e s
C l a s s : J P M T h e m a t i c s - G e n e t i c T h e r a pi e s C 2 ( a c c ) - U S D
Investments in themes or assets specifically related to sustainability.
"Article 8" strategies promote social and/or environmental
hiibdhiblii gp
characteristics, but do not have sustainable investing as a core
bji objective.
Fund overview ISIN Sedol Bloomberg Reuters LU2050612154 BHWTR91 JPGTC2A LX LU2050612154.LUF Investment objective: To achieve a return by investing in companies with exposure to the theme of genetic therapies, globally. Investment approach Uses the ThemeBot which, through natural language processing, determines textual relevance and revenue attribution to identify companies with the highest exposure to the theme. Considers insights from a team of specialist sector analysts who review the ThemeBot ’ s results to assess their appropriateness for the portfolio. Determines the position sizes of the securities identified as having the highest exposure to the theme by taking into consideration not only textual relevance and revenue attribution but also their quality, liquidity and market capitalisation.
ESG information ESG approach - Thematic
SFDR classification: Article 8
l
l
l
Portfolio manager(s) Yazann Romahi Aijaz Hussain Fund reference currency USD Share class currency USD
Fund assets USD 399.6m Fund launch 24 Oct 2019 NAV USD 139.37 Class launch 24 Oct 2019
Domicile Luxembourg Entry/exit charges Entry charge (max) 0.00% Exit charge (max) 0.00% Ongoing charge 0.45%
Fund ratings As at 30 September 2026
Performance
Quarterly rolling 12 - month performance (%) As at end of September 2026
Calendar Year Performance (%)
Return (%) Cumulative Annualised 1 month 3 months 1 year YTD 3 years 5 years Launch 0.49 5.21 36.02 20.78 13.24 - 3.47 4.90 - 1.11 1.60 16.75 13.03 21.73 11.57 13.37
Past performance is not a guide to current and future performance. The value of your investments and any income from them may fall as well as rise and you may not get back the full amount you invested.
For more information on our approach to sustainable investing at J.P. Morgan Asset Management please visit https://am.jpmorgan.com/lu/esg
Performance Disclosures
ESG
Morningstar Category™ Sector Equity Biotechnology
Class: JPM Thematics - Genetic Therapies C2 (acc) - USD Benchmark: MSCI All Country World Index (Total Return Net)
1 2 Growth of USD 100,000 Calendar years
30 Sep 2021 30 Sep 2026
2021/2022 2022/2023 2023/2024 2024/2025 2025/2026 - 34.55 - 11.80 8.20 - 1.33 36.02 - 20.66 20.80 31.76 17.27 16.75
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 - - - - 46.45 - 12.36 - 29.24 - 3.05 - 11.28 24.95 - - - - 16.25 18.54 - 18.36 22.20 17.49 22.34
Risk and Reward Profile Lower Risk Potentially lower reward Higher Risk Potentially higher reward
Page 2
Portfolio analysis Measurement 3 years 5 years Correlation 0.58 0.59 Alpha (%) - 6.97 - 13.48 Beta 1.03 0.84 Annualised volatility (%) 21.20 21.08 Sharpe ratio 0.48 - 0.24 Tracking error (%) 17.30 17.13 Information ratio - 0.33 - 0.78
Holdings As at 31 August 2026 Top 10 Sector % of assets Twist Bioscience Health Care 3.2 Amgen Health Care 3.1 Charles River Laboratories Health Care 3.1 Krystal Biotech Health Care 3.1 WuXi AppTec Health Care 3.1 Bristol - Myers Squibb Health Care 3.0 Gilead Sciences Health Care 3.0 Biogen Health Care 3.0 Arrowhead Pharmaceuticals Health Care 2.9 Novartis Health Care 2.8
Regions (%) As at 31 August 2026 Compared to benchmark North America 73.1 +6.5 Europe & Middle East ex UK 12.1 +1.1 Emerging Markets 7.3 - 4.6 Japan 4.3 - 0.8 United Kingdom 1.2 - 1.9 Pacific ex - Japan 1.2 - 1.1 Cash 0.8 +0.8 Figures shown may not add up to 100 due to rounding.
Page 2 of 3 | Factsheet | 30 September 2026 Class: JPM Thematics - Genetic Therapies C2 (acc) - USD
Page 3
Before investing, obtain and review the current prospectus, Key Investor Information Document (KIID), and any applicable local offering document. These documents as well as the sustainability related disclosures, annual and semi - annual reports and the articles of incorporation, are available in English from your financial adviser, your J.P. Morgan Asset Management regional contact, the fund ’ s issuer (see below) or at https://am.jpmorgan.com/gb/en/asset - management/per/. A summary of investor rights is available in English at https://am.jpmorgan.com/lu/investor - rights . J.P. Morgan Asset Management may decide to terminate the arrangements made for the marketing of its collective investment undertakings. This material should not be considered as advice or an investment recommendation. Fund holdings and performance are likely to have changed since the report date. To the extent permitted by applicable law, we may record telephone calls and monitor electronic communications to comply with our legal and regulatory obligations and internal policies. Personal data will be collected, stored and processed by J.P. Morgan Asset Management in accordance with our EMEA Privacy Policy www.jpmorgan.com/emea - privacy - policy . For additional information on the sub - fund ’ s target market please refer to the Prospectus. The risk indicator is based on the historic volatility of the Net Asset Value of the Share Class over the last five years and may not be a reliable indication of the future risk profile of the Share Class. The risk and reward category shown above is not guaranteed to remain unchanged and may change over time. A Share Class with the lowest risk rating does not mean a risk - free investment. See the Key Investor Information Document (KIID) for details.
Source: J.P. Morgan Asset Management. Share class performance is shown based on the NAV (net asset value) of the share class with income (gross) reinvested including actual ongoing charges excluding any entry and exit fees. The return of your investment may change as a result of currency
The Sub - Fund is subject to Investment risks and Other associated risks from the techniques and securities it uses to seek to achieve its objective. The table below explains how these risks relate to each other and the Outcomes to the Shareholder that could affect an investment in the Sub - Fund. Investors should also read Risk Descriptions in the Prospectus for a full description of each risk.
Key risks
Investment risks Risks from the Sub - Fund ’ s techniques and securities Techniques Concentration Hedging Thematic
Securities Emerging markets Equities
Smaller companies
General Disclosures
Performance information
▼ Other associated risks Further risks the Sub - Fund is exposed to from its use of the techniques and securities above Currency Liquidity Market ▼ Outcomes to the Shareholder Potential impact of the risks above Loss Shareholders could lose some or all of their money.
Volatility Shares of the Sub Fund will fluctuate in value.
Failure to meet the Sub - Fund ’ s objective.
fluctuations if your investment is made in a currency other than that used in the past performance calculation. Indices do not include fees or operating expenses and you cannot invest in them. The benchmark is for comparative purposes only unless specifically referenced in the Sub - Funds' Investment Objective and Policy.
Fund information, including performance calculations and other data, is provided by J.P. Morgan Asset Management (the marketing name for the asset management businesses of JPMorgan Chase & Co. and its affiliates worldwide). All data is as at the document date unless indicated otherwise. © 2025 Morningstar. All Rights Reserved. The information contained herein: (1) is proprietary to Morningstar; (2) may not be copied or distributed; and (3) is not warranted to be accurate, complete or timely. Neither Morningstar nor its content providers are responsible for any damages or losses arising from any use of this information. Benchmark Source: MSCI. Neither MSCI nor any other party involved in or related to compiling, computing or creating the MSCI data makes any express or implied warranties or representations with respect to such data (or the results to be obtained by the use thereof), and all such parties hereby expressly disclaim all warranties of originality, accuracy, completeness, merchantability or fitness for a particular purpose with respect to any of such data. Without limiting any of the foregoing, in no event shall MSCI, any of its affiliates or any third party involved, in or related to compiling, computing, or creating the data have any liability for any direct, indirect, special, punitive, consequential or any other damages (including lost profits) even if notified of the possibility of such damages. No further distribution or dissemination of the MSCI data is permitted without MSCI's express written consent.
JPMorgan Asset Management (UK) Limited Registered address: 25 Bank Street, Canary Wharf, London E14 5JP, United Kingdom. Authorised and regulated by the Financial Conduct Authority. Registered in England No. 01161446.
JPMorgan Asset Management (Europe) S.à r.l., 6, route de Trèves, L 2633 Senningerberg, Luxembourg. B27900, corporate capital EUR 10.000.000.
NAV Net Asset Value of a fund ’ s assets less its liabilities per Share. Correlation measures the strength and direction of the relationship between movements in fund and benchmark returns. A correlation of 1.00 indicates that fund and benchmark returns move in lockstep in the same direction. Alpha (%) a measure of excess return generated by a manager compared to the benchmark. An alpha of 1.00 indicates that a fund has outperformed its benchmark by 1%. Beta measures a fund ’ s sensitivity to market movements (as represented by the fund ’ s benchmark). A beta of 1.10 suggests the fund could perform 10% better than the benchmark in up markets and 10% worse in down markets, assuming all other factors remain constant. Usually the higher betas represent riskier investments. Annualised volatility (%) measures the extent to which returns vary up and down over a given period. Sharpe ratio performance of an investment adjusting for the amount of risk taken (compared a risk - free investment). The higher the Sharpe ratio the better the returns compared to the risk taken. Tracking error (%) measures how much a fund ’ s returns deviate from those of the benchmark. The lower the number the closer the fund ’ s historic performance has followed its benchmark. Information ratio measures if a manager is outperforming or underperforming the benchmark and accounts for the risk taken to achieve the returns. A manager who outperforms a benchmark by 2% p.a. will have a higher IR than a manager with the same outperformance but who takes more risk.
Information Sources
Regional Contact
Issuer
Definitions
Page 3 of 3 | Factsheet | 30 September 2026 Class: JPM Thematics - Genetic Therapies C2 (acc) - USD
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