{
  "annotation_id": "8c3cbc6e-e02d-4b50-87da-f1db16fecb6e",
  "date_created": "2026-03-02T18:01:35.533000Z",
  "date_modified": "2026-03-02T18:01:35.533000Z",
  "file_hash": "384c35ec7e02f6690245fa0dec3be8b1e048bf2abe83d54826c6fe6853a9eeaf",
  "private": false,
  "record": {
    "abstract": "DNA replication in Xenopus laevis is extremely reliable, failing to complete\nbefore cell division no more than once in 10,000 times; yet replication origins\nsites are located and initiated stochastically. Using a model based on 1d\ntheories of nucleation and growth and using concepts from extreme-value\nstatistics, we derive the distribution of replication times given a particular\ninitiation function. We show that the experimentally observed initiation\nstrategy for Xenopus laevis meets the reliability constraint and is close to\nthe one that requires the fewest resources of a cell.",
    "arxiv_id": "q-bio/0611016",
    "authors": [
      "John Bechhoefer",
      "Brandon Marshall"
    ],
    "categories": [
      "q-bio.CB",
      "q-bio.QM"
    ],
    "doi": "10.1103/PhysRevLett.98.098105",
    "journal_ref": "Phys. Rev. Lett. 98, 098105 (2007)",
    "title": "How Xenopus laevis replicates DNA reliably even though its origins of   replication are located and initiated stochastically",
    "url": "https://arxiv.org/abs/q-bio/0611016"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a0c7913c-a715-4b32-894a-1c66df4376f7",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}