dorsal/arxiv
View SchemaHow Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically
| Authors | John Bechhoefer, Brandon Marshall |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611016 |
| URL | https://arxiv.org/abs/q-bio/0611016 |
| DOI | 10.1103/PhysRevLett.98.098105 |
| Journal | Phys. Rev. Lett. 98, 098105 (2007) |
Abstract
DNA replication in Xenopus laevis is extremely reliable, failing to complete before cell division no more than once in 10,000 times; yet replication origins sites are located and initiated stochastically. Using a model based on 1d theories of nucleation and growth and using concepts from extreme-value statistics, we derive the distribution of replication times given a particular initiation function. We show that the experimentally observed initiation strategy for Xenopus laevis meets the reliability constraint and is close to the one that requires the fewest resources of a cell.
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"abstract": "DNA replication in Xenopus laevis is extremely reliable, failing to complete\nbefore cell division no more than once in 10,000 times; yet replication origins\nsites are located and initiated stochastically. Using a model based on 1d\ntheories of nucleation and growth and using concepts from extreme-value\nstatistics, we derive the distribution of replication times given a particular\ninitiation function. We show that the experimentally observed initiation\nstrategy for Xenopus laevis meets the reliability constraint and is close to\nthe one that requires the fewest resources of a cell.",
"arxiv_id": "q-bio/0611016",
"authors": [
"John Bechhoefer",
"Brandon Marshall"
],
"categories": [
"q-bio.CB",
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],
"doi": "10.1103/PhysRevLett.98.098105",
"journal_ref": "Phys. Rev. Lett. 98, 098105 (2007)",
"title": "How Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically",
"url": "https://arxiv.org/abs/q-bio/0611016"
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