dorsal/arxiv
View SchemaDetailed analysis of the response of different cell lines to carbon irradiation
| Authors | Hana Hromčíková, Pavel Kundrát, Miloš Lokajíček |
|---|---|
| Categories | |
| ArXiv ID | physics/0512044 |
| URL | https://arxiv.org/abs/physics/0512044 |
Abstract
Published survival data for Chinese hamster ovarian cells CHO-K1 and their radiosensitive mutant xrs5 after irradiation by carbon ions of energies from 2.4 to 266.4 MeV/u have been analyzed using the probabilistic two-stage radiobiological model, which enables to represent the interplay of damage induction and repair processes. The results give support for the hypothesis that the differences in radiation sensitivity of diverse cell lines are given primarily by their different repair capabilities, and indicate the need for explicitly representing the outcome of repair processes in radiobiological models and treatment planning approaches in radiotherapy.
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"date_created": "2026-03-02T18:01:03.608000Z",
"date_modified": "2026-03-02T18:01:03.608000Z",
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"abstract": "Published survival data for Chinese hamster ovarian cells CHO-K1 and their\nradiosensitive mutant xrs5 after irradiation by carbon ions of energies from\n2.4 to 266.4 MeV/u have been analyzed using the probabilistic two-stage\nradiobiological model, which enables to represent the interplay of damage\ninduction and repair processes. The results give support for the hypothesis\nthat the differences in radiation sensitivity of diverse cell lines are given\nprimarily by their different repair capabilities, and indicate the need for\nexplicitly representing the outcome of repair processes in radiobiological\nmodels and treatment planning approaches in radiotherapy.",
"arxiv_id": "physics/0512044",
"authors": [
"Hana Hrom\u010d\u00edkov\u00e1",
"Pavel Kundr\u00e1t",
"Milo\u0161 Lokaj\u00ed\u010dek"
],
"categories": [
"physics.bio-ph"
],
"title": "Detailed analysis of the response of different cell lines to carbon irradiation",
"url": "https://arxiv.org/abs/physics/0512044"
},
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"execution_id": "36a19ed5-2102-4e83-8142-3270f9172578",
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"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
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