dorsal/arxiv
View SchemaModeling of anti-tumor immune response: immunocorrective effect of weak centimeter electromagnetic waves
| Authors | O. G. Isaeva, V. A. Osipov |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0506006 |
| URL | https://arxiv.org/abs/q-bio/0506006 |
| License | http://arxiv.org/licenses/nonexclusive-distrib/1.0/ |
Abstract
We formulate the dynamical model for the anti-tumor immune response based on intercellular cytokine-mediated interactions with the interleukin-2 (IL-2) taken into account. The analysis shows that the expression level of tumor antigens on antigen presenting cells has a distinct influence on the tumor dynamics. At low antigen presentation a progressive tumor growth takes place to the highest possible value. At high antigen presentation there is a decrease in tumor size to some value when the dynamical equilibrium between the tumor and the immune system is reached. In the case of the medium antigen presentation both these regimes can be realized depending on the initial tumor size and the condition of the immune system. A pronounced immunomodulating effect (the suppression of tumor growth and the normalization of IL-2 concentration) is established by considering the influence of low-intensity electromagnetic microwaves as a parametric perturbation of the dynamical system. This finding is in qualitative agreement with the recent experimental results on immunocorrective effects of centimeter electromagnetic waves in tumor-bearing mice.
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"abstract": "We formulate the dynamical model for the anti-tumor immune response based on\nintercellular cytokine-mediated interactions with the interleukin-2 (IL-2)\ntaken into account. The analysis shows that the expression level of tumor\nantigens on antigen presenting cells has a distinct influence on the tumor\ndynamics. At low antigen presentation a progressive tumor growth takes place to\nthe highest possible value. At high antigen presentation there is a decrease in\ntumor size to some value when the dynamical equilibrium between the tumor and\nthe immune system is reached. In the case of the medium antigen presentation\nboth these regimes can be realized depending on the initial tumor size and the\ncondition of the immune system. A pronounced immunomodulating effect (the\nsuppression of tumor growth and the normalization of IL-2 concentration) is\nestablished by considering the influence of low-intensity electromagnetic\nmicrowaves as a parametric perturbation of the dynamical system. This finding\nis in qualitative agreement with the recent experimental results on\nimmunocorrective effects of centimeter electromagnetic waves in tumor-bearing\nmice.",
"arxiv_id": "q-bio/0506006",
"authors": [
"O. G. Isaeva",
"V. A. Osipov"
],
"categories": [
"q-bio.CB",
"q-bio.PE"
],
"license": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
"title": "Modeling of anti-tumor immune response: immunocorrective effect of weak centimeter electromagnetic waves",
"url": "https://arxiv.org/abs/q-bio/0506006"
},
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"type": "Model",
"variant": "snapshot-2026-03-01",
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