dorsal/arxiv
View SchemaFolding DNA into nucleosome and chromatin: dynamics
| Authors | Thomas C. Bishop, Oleksandr O. Zhmudsky |
|---|---|
| Categories | |
| ArXiv ID | physics/0108008 |
| URL | https://arxiv.org/abs/physics/0108008 |
Abstract
A theoretical framework for evaluating the approximate energy and dynamic properties associated with the folding of DNA into nucleosomes and chromatin is presented. For this purpose experimentally determined elastic constants of linear DNA and a simple fold geometry are assumed to derive constants for the higher order folding. The model predicts the correct order of magnitude for the experimentally determined Young's and shear modulus of condensed chromatin. Thus we have demonstrated that the elastic properties of DNA are the primary determinant of the elastic properties of each folded state. The derived elastic constants are then used to predict the speed of propagation of small amplitude waves. It is shown that extension/compression, twist, bend or shear waves can be excite in each folded state.
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"abstract": "A theoretical framework for evaluating the approximate energy and dynamic\nproperties associated with the folding of DNA into nucleosomes and chromatin is\npresented. For this purpose experimentally determined elastic constants of\nlinear DNA and a simple fold geometry are assumed to derive constants for the\nhigher order folding. The model predicts the correct order of magnitude for the\nexperimentally determined Young\u0027s and shear modulus of condensed chromatin.\nThus we have demonstrated that the elastic properties of DNA are the primary\ndeterminant of the elastic properties of each folded state. The derived elastic\nconstants are then used to predict the speed of propagation of small amplitude\nwaves. It is shown that extension/compression, twist, bend or shear waves can\nbe excite in each folded state.",
"arxiv_id": "physics/0108008",
"authors": [
"Thomas C. Bishop",
"Oleksandr O. Zhmudsky"
],
"categories": [
"physics.bio-ph",
"q-bio"
],
"title": "Folding DNA into nucleosome and chromatin: dynamics",
"url": "https://arxiv.org/abs/physics/0108008"
},
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