dorsal/arxiv
View SchemaPhysics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms
| Authors | Debashish Chowdhury, Andreas Schadschneider, Katsuhiro Nishinari |
|---|---|
| Categories | |
| ArXiv ID | physics/0509025 |
| URL | https://arxiv.org/abs/physics/0509025 |
| DOI | 10.1016/j.plrev.2005.09.001 |
| Journal | PHYSICS OF LIFE REVIEWS (Elsevier), vol.2, 318 (2005) |
Abstract
Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells, sometimes encounter traffic jam that manifests as a disease of the organism. Similarly, traffic jam of collagenase MMP-1, which moves on the collagen fibrils of the extracellular matrix of vertebrates, has also been observed in recent experiments. Traffic-like movements of social insects like ants and termites on trails are, perhaps, more familiar in our everyday life. Experimental, theoretical and computational investigations in the last few years have led to a deeper understanding of the generic or common physical principles involved in these phenomena. In particular, some of the methods of non-equilibrium statistical mechanics, pioneered almost a hundred years ago by Einstein, Langevin and others, turned out to be powerful theoretical tools for quantitaive analysis of models of these traffic-like collective phenomena as these systems are intrinsically far from equilibrium. In this review we critically examine the current status of our understanding, expose the limitations of the existing methods, mention open challenging questions and speculate on the possible future directions of research in this interdisciplinary area where physics meets not only chemistry and biology but also (nano-)technology.
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"abstract": "Traffic-like collective movements are observed at almost all levels of\nbiological systems. Molecular motor proteins like, for example, kinesin and\ndynein, which are the vehicles of almost all intra-cellular transport in\neukayotic cells, sometimes encounter traffic jam that manifests as a disease of\nthe organism. Similarly, traffic jam of collagenase MMP-1, which moves on the\ncollagen fibrils of the extracellular matrix of vertebrates, has also been\nobserved in recent experiments. Traffic-like movements of social insects like\nants and termites on trails are, perhaps, more familiar in our everyday life.\nExperimental, theoretical and computational investigations in the last few\nyears have led to a deeper understanding of the generic or common physical\nprinciples involved in these phenomena. In particular, some of the methods of\nnon-equilibrium statistical mechanics, pioneered almost a hundred years ago by\nEinstein, Langevin and others, turned out to be powerful theoretical tools for\nquantitaive analysis of models of these traffic-like collective phenomena as\nthese systems are intrinsically far from equilibrium. In this review we\ncritically examine the current status of our understanding, expose the\nlimitations of the existing methods, mention open challenging questions and\nspeculate on the possible future directions of research in this\ninterdisciplinary area where physics meets not only chemistry and biology but\nalso (nano-)technology.",
"arxiv_id": "physics/0509025",
"authors": [
"Debashish Chowdhury",
"Andreas Schadschneider",
"Katsuhiro Nishinari"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech"
],
"doi": "10.1016/j.plrev.2005.09.001",
"journal_ref": "PHYSICS OF LIFE REVIEWS (Elsevier), vol.2, 318 (2005)",
"title": "Physics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms",
"url": "https://arxiv.org/abs/physics/0509025"
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