{
  "annotation_id": "88f6f521-5728-476d-975b-f97c8cb44d4b",
  "date_created": "2026-03-02T18:01:35.332000Z",
  "date_modified": "2026-03-02T18:01:35.332000Z",
  "file_hash": "7b6e8efb78c455bcf95f438ed4e345074c36c388533aa24c5d2f1e07e4a8a1b4",
  "private": false,
  "record": {
    "abstract": "We derive a physiologically structured multiscale model for biofilm\ndevelopment. The model has components on two spatial scales, which induce\ndifferent time scales into the problem. The macroscopic behavior of the system\nis modeled using growth-induced flow in a domain with a moving boundary.\nCell-level processes are incorporated into the model using a so-called\nphysiologically structured variable to represent cell senescence, which in turn\naffects cell division and mortality. We present computational results for our\nmodels which shed light on modeling the combined role senescence and the\nbiofilm state play in the defense strategy of bacteria.",
    "arxiv_id": "q-bio/0609019",
    "authors": [
      "Bruce P. Ayati",
      "Isaac Klapper"
    ],
    "categories": [
      "q-bio.CB"
    ],
    "doi": "10.1137/060669796",
    "journal_ref": "Multiscale Modeling \u0026 Simulation, Vol. 6, No. 2, pp. 347-365, 2007",
    "title": "A Multiscale Model of Biofilm as a Senescence-Structured Fluid",
    "url": "https://arxiv.org/abs/q-bio/0609019"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a0818e3d-0d20-4e37-bd2e-44329493f564",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}