dorsal/arxiv
View SchemaRobustness and fragility of Boolean models for genetic regulatory networks
| Authors | Madalena Chaves, Reka Albert, Eduardo D. Sontag |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0501037 |
| URL | https://arxiv.org/abs/q-bio/0501037 |
| Journal | Journal of Theoretical Biology 235, 431-449 (2005) |
Abstract
Interactions between genes and gene products give rise to complex circuits that enable cells to process information and respond to external signals. Theoretical studies often describe these interactions using continuous, stochastic, or logical approaches. We propose a new modeling framework for gene regulatory networks, that combines the intuitive appeal of a qualitative description of gene states with a high flexibility in incorporating stochasticity in the duration of cellular processes. We apply our methods to the regulatory network of the segment polarity genes, thus gaining novel insights into the development of gene expression patterns. For example, we show that very short synthesis and decay times can perturb the wild type pattern. On the other hand, separation of timescales between pre- and posttranslational processes and a minimal prepattern ensure convergence to the wild type expression pattern regardless of fluctuations.
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"abstract": "Interactions between genes and gene products give rise to complex circuits\nthat enable cells to process information and respond to external signals.\nTheoretical studies often describe these interactions using continuous,\nstochastic, or logical approaches. We propose a new modeling framework for gene\nregulatory networks, that combines the intuitive appeal of a qualitative\ndescription of gene states with a high flexibility in incorporating\nstochasticity in the duration of cellular processes. We apply our methods to\nthe regulatory network of the segment polarity genes, thus gaining novel\ninsights into the development of gene expression patterns. For example, we show\nthat very short synthesis and decay times can perturb the wild type pattern. On\nthe other hand, separation of timescales between pre- and posttranslational\nprocesses and a minimal prepattern ensure convergence to the wild type\nexpression pattern regardless of fluctuations.",
"arxiv_id": "q-bio/0501037",
"authors": [
"Madalena Chaves",
"Reka Albert",
"Eduardo D. Sontag"
],
"categories": [
"q-bio.MN"
],
"journal_ref": "Journal of Theoretical Biology 235, 431-449 (2005)",
"title": "Robustness and fragility of Boolean models for genetic regulatory networks",
"url": "https://arxiv.org/abs/q-bio/0501037"
},
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