{
  "annotation_id": "853d710e-467e-4699-a928-60b50185a07f",
  "date_created": "2026-03-02T18:01:31.862000Z",
  "date_modified": "2026-03-02T18:01:31.862000Z",
  "file_hash": "a3caae465f1e1de43b5b0589e7c53ef60630b34d127f594f3ff2c6ef479a6d73",
  "private": false,
  "record": {
    "abstract": "The complexity of a neuronal cell shape is known to be related to its\nfunction. Specifically, among other indicators, a decreased complexity in the\ndendritic trees of cortical pyramidal neurons has been associated with mental\nretardation. In this paper we develop a procedure to address the\ncharacterization of morphological changes induced in cultured neurons by\nover-expressing a gene involved in mental retardation. Measures associated with\nthe multiscale connectivity, an additive image functional, are found to give a\nreasonable separation criterion between two categories of cells. One category\nconsists of a control group and two transfected groups of neurons, and the\nother, a class of cat ganglionary cells. The reported framework also identified\na trend towards lower complexity in one of the transfected groups. Such results\nestablish the suggested measures as an effective descriptors of cell shape.",
    "arxiv_id": "q-bio/0408004",
    "authors": [
      "M. S. Barbosa",
      "L. da F. Costa",
      "E. S. Bernardes",
      "G. Ramakers",
      "J. van Pelt"
    ],
    "categories": [
      "q-bio.QM",
      "cond-mat.stat-mech"
    ],
    "doi": "10.1140/epjb/e2004-00035-y",
    "journal_ref": "Eur. Phys. J. B 37, 109 115 (2004)",
    "title": "Characterizing neuromorphologic alterations with additive shape   functionals",
    "url": "https://arxiv.org/abs/q-bio/0408004"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "cf02c07b-ded1-44aa-b538-2e1f39bfba10",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}