dorsal/arxiv
View SchemaModeling the Role of the Cell Cycle in Regulating Proteus mirabilis Swarm-Colony Development
| Authors | Bruce P. Ayati |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507027 |
| URL | https://arxiv.org/abs/q-bio/0507027 |
| DOI | 10.1016/j.aml.2006.11.003 |
| Journal | Applied Mathematics Letters, Vol. 20, 2007, pp. 913-918 |
Abstract
We present models and computational results which indicate that the spatial and temporal regularity seen in Proteus mirabilis swarm-colony development is largely an expression of a sharp age of dedifferentiation in the cell cycle from motile swarmer cells to immotile dividing cells (also called swimmer or vegetative cells.) This contrasts strongly with reaction-diffusion models of Proteus behavior that ignore or average out the age structure of the cell population and instead use only density-dependent mechanisms. We argue the necessity of retaining the explicit age structure, and suggest experiments that may help determine the underlying mechanisms empirically. Consequently, we advocate Proteus as a model organism for a multiscale understanding of how and to what extent the life cycle of individual cells affects the macroscopic behavior of a biological system.
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"abstract": "We present models and computational results which indicate that the spatial\nand temporal regularity seen in Proteus mirabilis swarm-colony development is\nlargely an expression of a sharp age of dedifferentiation in the cell cycle\nfrom motile swarmer cells to immotile dividing cells (also called swimmer or\nvegetative cells.) This contrasts strongly with reaction-diffusion models of\nProteus behavior that ignore or average out the age structure of the cell\npopulation and instead use only density-dependent mechanisms. We argue the\nnecessity of retaining the explicit age structure, and suggest experiments that\nmay help determine the underlying mechanisms empirically. Consequently, we\nadvocate Proteus as a model organism for a multiscale understanding of how and\nto what extent the life cycle of individual cells affects the macroscopic\nbehavior of a biological system.",
"arxiv_id": "q-bio/0507027",
"authors": [
"Bruce P. Ayati"
],
"categories": [
"q-bio.CB",
"q-bio.QM"
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"doi": "10.1016/j.aml.2006.11.003",
"journal_ref": "Applied Mathematics Letters, Vol. 20, 2007, pp. 913-918",
"title": "Modeling the Role of the Cell Cycle in Regulating Proteus mirabilis Swarm-Colony Development",
"url": "https://arxiv.org/abs/q-bio/0507027"
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