dorsal/arxiv
View SchemaUniversal collective fluctuations in gene expression dynamics from yeast to human
| Authors | J. C. Nacher, T. Ochiai, T. Akutsu |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0503004 |
| URL | https://arxiv.org/abs/q-bio/0503004 |
Abstract
In this work, the dynamics of fluctuations in gene expression time series is investigated. By using collected data of gene expression from yeast and human organisms, we found that the fluctuations of gene expression level and its average value over time are strongly correlated and obey a scaling law. As this feature is found in yeast and human organisms, it suggests that probably this coupling is a common dynamical organizing property of all living systems. To understand these observations, we propose a stochastic model which can explain these collective fluctuations, and predict the scaling exponent. Interestingly, our results indicate that the observed scaling law emerges from the self-similarity symmetry embedded in gene expression fluctuations.
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"abstract": "In this work, the dynamics of fluctuations in gene expression time series is\ninvestigated. By using collected data of gene expression from yeast and human\norganisms, we found that the fluctuations of gene expression level and its\naverage value over time are strongly correlated and obey a scaling law. As this\nfeature is found in yeast and human organisms, it suggests that probably this\ncoupling is a common dynamical organizing property of all living systems. To\nunderstand these observations, we propose a stochastic model which can explain\nthese collective fluctuations, and predict the scaling exponent. Interestingly,\nour results indicate that the observed scaling law emerges from the\nself-similarity symmetry embedded in gene expression fluctuations.",
"arxiv_id": "q-bio/0503004",
"authors": [
"J. C. Nacher",
"T. Ochiai",
"T. Akutsu"
],
"categories": [
"q-bio.BM"
],
"title": "Universal collective fluctuations in gene expression dynamics from yeast to human",
"url": "https://arxiv.org/abs/q-bio/0503004"
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