{
  "annotation_id": "8225b33d-e42b-46ee-8aaf-c8d70101dca6",
  "date_created": "2026-03-02T18:01:28.466000Z",
  "date_modified": "2026-03-02T18:01:28.466000Z",
  "file_hash": "65d84f76cb23ecb4377e08d72502784b9941b1375a370ed1f0757fbfde1c3800",
  "private": false,
  "record": {
    "abstract": "Dynamics maintaining diversity of cell types in a multi-cellular system are\nstudied in relationship with the plasticity of cellular states. By adopting a\nsimple theoretical framework for intra-cellular chemical reaction dynamics with\nconsidering the division and death of cells, developmental process from a\nsingle cell is studied. Cell differentiation process is found to occur through\ninstability in transient dynamics and cell-cell interaction. In a long time\nbehavior, extinction of multiple cells is repeated, which leads to itinerancy\nover successive quasi-stable multi-cellular states consisting of different\ntypes of cells. By defining the plasticity of a cellular state, it is shown\nthat the plasticity of cells decreases before the large extinction, from which\ndiversity and plasticity are recovered. After this switching, decrease of\nplasticity again occurs, leading to the next extinction of multiple cells. This\ncycle of diversification and extinction is repeated. Relevance of our results\nto the development and evolution is briefly discussed.",
    "arxiv_id": "q-bio/0311029",
    "authors": [
      "Hiroaki Takagi",
      "Kunihiko Kaneko"
    ],
    "categories": [
      "q-bio.CB",
      "q-bio.TO"
    ],
    "title": "Dynamical Systems Basis of Metamorphosis: Diversity and Plasticity of   Cellular States in Reaction Diffusion Network",
    "url": "https://arxiv.org/abs/q-bio/0311029"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "8719d941-20be-4521-92ac-9bc95e3651ad",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}