dorsal/arxiv
View SchemaModeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors
| Authors | Luis Diambra |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0405024 |
| URL | https://arxiv.org/abs/q-bio/0405024 |
Abstract
We focused our attention on Ca$^{2+}$ release from the endoplasmic reticulum through a cluster of inositol 1,4,5-trisphosphate (IP$_3$) receptor channels. The random opening and closing of these receptors introduce stochastic effects that have been observed experimentally. Here, we present a stochastic version of Othmer-Tang model for IP$_3$ receptor clusters. We address the average behavior of the channels in response to IP$_3$ stimuli. We found, by stochastic simulation, that the shape of the receptor response to IP$_3$ (fraction of open channels versus [IP$_3$]), is affected by the cytosolic Ca$^{2+}$ level. We also study several aspects of the stochastic properties of Ca${2+}$ release and we compare with experimental observations.
{
"annotation_id": "7fcc154e-037d-49b8-811b-9a55b9b091ed",
"date_created": "2026-03-02T18:01:31.026000Z",
"date_modified": "2026-03-02T18:01:31.026000Z",
"file_hash": "610d65aaac0f2a1848811056b54fc9e81aa71da4af5229930424e3bb98392d7c",
"private": false,
"record": {
"abstract": "We focused our attention on Ca$^{2+}$ release from the endoplasmic reticulum\nthrough a cluster of inositol 1,4,5-trisphosphate (IP$_3$) receptor channels.\nThe random opening and closing of these receptors introduce stochastic effects\nthat have been observed experimentally. Here, we present a stochastic version\nof Othmer-Tang model for IP$_3$ receptor clusters. We address the average\nbehavior of the channels in response to IP$_3$ stimuli. We found, by stochastic\nsimulation, that the shape of the receptor response to IP$_3$ (fraction of open\nchannels versus [IP$_3$]), is affected by the cytosolic Ca$^{2+}$ level. We\nalso study several aspects of the stochastic properties of Ca${2+}$ release and\nwe compare with experimental observations.",
"arxiv_id": "q-bio/0405024",
"authors": [
"Luis Diambra"
],
"categories": [
"q-bio.SC"
],
"title": "Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors",
"url": "https://arxiv.org/abs/q-bio/0405024"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "92949197-fc1b-4468-8466-f359b3b7279d",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}