{
  "annotation_id": "7fcc154e-037d-49b8-811b-9a55b9b091ed",
  "date_created": "2026-03-02T18:01:31.026000Z",
  "date_modified": "2026-03-02T18:01:31.026000Z",
  "file_hash": "610d65aaac0f2a1848811056b54fc9e81aa71da4af5229930424e3bb98392d7c",
  "private": false,
  "record": {
    "abstract": "We focused our attention on Ca$^{2+}$ release from the endoplasmic reticulum\nthrough a cluster of inositol 1,4,5-trisphosphate (IP$_3$) receptor channels.\nThe random opening and closing of these receptors introduce stochastic effects\nthat have been observed experimentally. Here, we present a stochastic version\nof Othmer-Tang model for IP$_3$ receptor clusters. We address the average\nbehavior of the channels in response to IP$_3$ stimuli. We found, by stochastic\nsimulation, that the shape of the receptor response to IP$_3$ (fraction of open\nchannels versus [IP$_3$]), is affected by the cytosolic Ca$^{2+}$ level. We\nalso study several aspects of the stochastic properties of Ca${2+}$ release and\nwe compare with experimental observations.",
    "arxiv_id": "q-bio/0405024",
    "authors": [
      "Luis Diambra"
    ],
    "categories": [
      "q-bio.SC"
    ],
    "title": "Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive   receptors",
    "url": "https://arxiv.org/abs/q-bio/0405024"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "92949197-fc1b-4468-8466-f359b3b7279d",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}