dorsal/arxiv
View SchemaCooperativity, sensitivity and noise in biochemical signaling
| Authors | William Bialek, Sima Setayeshgar |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0601001 |
| URL | https://arxiv.org/abs/q-bio/0601001 |
Abstract
Cooperative interactions among the binding of multiple signaling molecules is a common mechanism for enhancing the sensitivity of biological signaling systems. It is widely assumed that this increase in sensitivity of the mean response implies the ability to detect smaller signals. We show that, quite generally, there is a component of the noise in such systems that can be traced to the random arrival of the signaling molecules at their receptor sites, and this diffusive noise is not reduced by cooperativity. Cooperativity makes it easier for real systems to reach this physical limit, but cannot reduce the limit itself.
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"abstract": "Cooperative interactions among the binding of multiple signaling molecules is\na common mechanism for enhancing the sensitivity of biological signaling\nsystems. It is widely assumed that this increase in sensitivity of the mean\nresponse implies the ability to detect smaller signals. We show that, quite\ngenerally, there is a component of the noise in such systems that can be traced\nto the random arrival of the signaling molecules at their receptor sites, and\nthis diffusive noise is not reduced by cooperativity. Cooperativity makes it\neasier for real systems to reach this physical limit, but cannot reduce the\nlimit itself.",
"arxiv_id": "q-bio/0601001",
"authors": [
"William Bialek",
"Sima Setayeshgar"
],
"categories": [
"q-bio.MN",
"q-bio.SC"
],
"title": "Cooperativity, sensitivity and noise in biochemical signaling",
"url": "https://arxiv.org/abs/q-bio/0601001"
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