dorsal/arxiv
View SchemaRobustness in Gene Circuits: Clustering of Functional Responses
| Authors | Mary J. Dunlop, Michael E. Wall |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0503005 |
| URL | https://arxiv.org/abs/q-bio/0503005 |
Abstract
In contrast to engineering applications, in which the structure of control laws are designed to satisfy prescribed function requirements, in biology it is often necessary to infer gene-circuit function from incomplete data on gene-circuit structure. By using the feed-forward loop as a model system, this paper introduces a technique for classifying gene-circuit function given gene-circuit structure. In simulations performed on a comprehensive set of models that span a broad range of parameter space, some designs are robust, producing one unique type of functional response regardless of parameter selection. Other designs may exhibit a variety of functional responses, depending upon parameter values. We conclude that, although some feed-forward loop models have designs that lend themselves to unique function inference, others have designs for which the function type may be uncertain.
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"abstract": "In contrast to engineering applications, in which the structure of control\nlaws are designed to satisfy prescribed function requirements, in biology it is\noften necessary to infer gene-circuit function from incomplete data on\ngene-circuit structure. By using the feed-forward loop as a model system, this\npaper introduces a technique for classifying gene-circuit function given\ngene-circuit structure. In simulations performed on a comprehensive set of\nmodels that span a broad range of parameter space, some designs are robust,\nproducing one unique type of functional response regardless of parameter\nselection. Other designs may exhibit a variety of functional responses,\ndepending upon parameter values. We conclude that, although some feed-forward\nloop models have designs that lend themselves to unique function inference,\nothers have designs for which the function type may be uncertain.",
"arxiv_id": "q-bio/0503005",
"authors": [
"Mary J. Dunlop",
"Michael E. Wall"
],
"categories": [
"q-bio.MN"
],
"title": "Robustness in Gene Circuits: Clustering of Functional Responses",
"url": "https://arxiv.org/abs/q-bio/0503005"
},
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"variant": "snapshot-2026-03-01",
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