{
  "annotation_id": "7c40600b-b104-4b0f-a9c5-e210120911c9",
  "date_created": "2026-03-02T18:01:35.747000Z",
  "date_modified": "2026-03-02T18:01:35.747000Z",
  "file_hash": "6d081a191a0a21f0191d9d6faa4a5e4c1e746d418812c3955d075afd4dc14c81",
  "private": false,
  "record": {
    "abstract": "Despite tremendous advances in the field of genomics, the amount and function\nof the large non-coding part of the genome in higher organisms remains poorly\nunderstood. Here we report an observation, made for 37 fully sequenced\neukaryotic genomes, which indicates that eukaryotes require a certain minimum\namount of non-coding DNA (ncDNA). This minimum increases quadratically with the\namount of DNA located in exons. Based on a simple model of the growth of\nregulatory networks, we derive a theoretical prediction of the required\nquantity of ncDNA and find it to be in excellent agreement with the data. The\namount of additional ncDNA (in basepairs) which eukaryotes require obeys Ndef =\n1/2 (Nc / Np) (Nc - Np), where Nc is the amount of exonic DNA, and Np is a\nconstant of about 10Mb. This value Ndef corresponds to a few percent of the\ngenome in Homo sapiens and other mammals, and up to half the genome in simpler\neukaryotes. Thus our findings confirm that eukaryotic life depends on a\nsubstantial fraction of ncDNA and also make a prediction of the size of this\nfraction, which matches the data closely.",
    "arxiv_id": "q-bio/0611047",
    "authors": [
      "Sebastian Ahnert",
      "Thomas Fink",
      "Andrei Zinovyev"
    ],
    "categories": [
      "q-bio.GN"
    ],
    "title": "How much non-coding DNA do eukaryotes require?",
    "url": "https://arxiv.org/abs/q-bio/0611047"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a03ea605-8358-4b4c-b851-d1f3d1d021ca",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}