dorsal/arxiv
View SchemaThe role of cell-cell adhesion in wound healing
| Authors | Evgeniy Khain, Leonard M. Sander, Casey M. Schneider-Mizell |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0610015 |
| URL | https://arxiv.org/abs/q-bio/0610015 |
| DOI | 10.1007/s10955-006-9194-8 |
Abstract
We present a stochastic model which describes fronts of cells invading a wound. In the model cells can move, proliferate, and experience cell-cell adhesion. We find several qualitatively different regimes of front motion and analyze the transitions between them. Above a critical value of adhesion and for small proliferation large isolated clusters are formed ahead of the front. This is mapped onto the well-known ferromagnetic phase transition in the Ising model. For large adhesion, and larger proliferation the clusters become connected (at some fixed time). For adhesion below the critical value the results are similar to our previous work which neglected adhesion. The results are compared with experiments, and possible directions of future work are proposed.
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"abstract": "We present a stochastic model which describes fronts of cells invading a\nwound. In the model cells can move, proliferate, and experience cell-cell\nadhesion. We find several qualitatively different regimes of front motion and\nanalyze the transitions between them. Above a critical value of adhesion and\nfor small proliferation large isolated clusters are formed ahead of the front.\nThis is mapped onto the well-known ferromagnetic phase transition in the Ising\nmodel. For large adhesion, and larger proliferation the clusters become\nconnected (at some fixed time). For adhesion below the critical value the\nresults are similar to our previous work which neglected adhesion. The results\nare compared with experiments, and possible directions of future work are\nproposed.",
"arxiv_id": "q-bio/0610015",
"authors": [
"Evgeniy Khain",
"Leonard M. Sander",
"Casey M. Schneider-Mizell"
],
"categories": [
"q-bio.CB"
],
"doi": "10.1007/s10955-006-9194-8",
"title": "The role of cell-cell adhesion in wound healing",
"url": "https://arxiv.org/abs/q-bio/0610015"
},
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