dorsal/arxiv
View SchemaFlow correlated percolation during vascular network formation in tumors
| Authors | D. -S. Lee, H. Rieger, K. Bartha |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507043 |
| URL | https://arxiv.org/abs/q-bio/0507043 |
| DOI | 10.1103/PhysRevLett.96.058104 |
| Journal | Phys. Rev. Lett. 96, 058104 (2006) |
Abstract
A theoretical model based on the molecular interactions between a growing tumor and a dynamically evolving blood vessel network describes the transformation of the regular vasculature in normal tissues into a highly inhomogeneous tumor specific capillary network. The emerging morphology, characterized by the compartmentalization of the tumor into several regions differing in vessel density, diameter and necrosis, is in accordance with experimental data for human melanoma. Vessel collapse due to a combination of severely reduced blood flow and solid stress exerted by the tumor, leads to a correlated percolation process that is driven towards criticality by the mechanism of hydrodynamic vessel stabilization.
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"abstract": "A theoretical model based on the molecular interactions between a growing\ntumor and a dynamically evolving blood vessel network describes the\ntransformation of the regular vasculature in normal tissues into a highly\ninhomogeneous tumor specific capillary network. The emerging morphology,\ncharacterized by the compartmentalization of the tumor into several regions\ndiffering in vessel density, diameter and necrosis, is in accordance with\nexperimental data for human melanoma. Vessel collapse due to a combination of\nseverely reduced blood flow and solid stress exerted by the tumor, leads to a\ncorrelated percolation process that is driven towards criticality by the\nmechanism of hydrodynamic vessel stabilization.",
"arxiv_id": "q-bio/0507043",
"authors": [
"D. -S. Lee",
"H. Rieger",
"K. Bartha"
],
"categories": [
"q-bio.TO"
],
"doi": "10.1103/PhysRevLett.96.058104",
"journal_ref": "Phys. Rev. Lett. 96, 058104 (2006)",
"title": "Flow correlated percolation during vascular network formation in tumors",
"url": "https://arxiv.org/abs/q-bio/0507043"
},
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