dorsal/arxiv
View SchemaRandom Boolean Network Models and the Yeast Transcriptional Network
| Authors | Stuart Kauffman, Carsten Peterson, Björn Samuelsson, Carl Troein |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0401002 |
| URL | https://arxiv.org/abs/q-bio/0401002 |
| DOI | 10.1073/pnas.2036429100 |
| Journal | Proc. Natl. Acad. Sci. USA 100 (2003) 14796-14799 |
Abstract
The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.
{
"annotation_id": "7a637794-f11e-4248-9ba0-09d749e6c1c5",
"date_created": "2026-03-02T18:01:31.818000Z",
"date_modified": "2026-03-02T18:01:31.818000Z",
"file_hash": "3f15201b3c261a7509fe1fed12cb3dd913b8e5a716660019bb0e5ebb66b8c6d2",
"private": false,
"record": {
"abstract": "The recently measured yeast transcriptional network is analyzed in terms of\nsimplified Boolean network models, with the aim of determining feasible rule\nstructures, given the requirement of stable solutions of the generated Boolean\nnetworks. We find that for ensembles of generated models, those with canalyzing\nBoolean rules are remarkably stable, whereas those with random Boolean rules\nare only marginally stable. Furthermore, substantial parts of the generated\nnetworks are frozen, in the sense that they reach the same state regardless of\ninitial state. Thus, our ensemble approach suggests that the yeast network\nshows highly ordered dynamics.",
"arxiv_id": "q-bio/0401002",
"authors": [
"Stuart Kauffman",
"Carsten Peterson",
"Bj\u00f6rn Samuelsson",
"Carl Troein"
],
"categories": [
"q-bio.MN",
"cond-mat.soft"
],
"doi": "10.1073/pnas.2036429100",
"journal_ref": "Proc. Natl. Acad. Sci. USA 100 (2003) 14796-14799",
"title": "Random Boolean Network Models and the Yeast Transcriptional Network",
"url": "https://arxiv.org/abs/q-bio/0401002"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "b279d2e8-83ab-4041-8297-a064f718cdb4",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}