dorsal/arxiv
View SchemaA Coarse-Grained Lattice Model for Molecular Recognition
| Authors | Hans Behringer, Andreas Degenhard, Friederike Schmid |
|---|---|
| Categories | |
| ArXiv ID | physics/0608234 |
| URL | https://arxiv.org/abs/physics/0608234 |
| DOI | 10.1103/PhysRevLett.97.128101 |
| Journal | Phys. Rev. Lett. 97, 128101 (2006) |
Abstract
We present a simple model which allows to investigate equilibrium aspects of molecular recognition between rigid biomolecules on a generic level. Using a two-stage approach, which consists of a design and a testing step, the role of cooperativity and of varying bond strength in molecular recognition is investigated. Cooperativity is found to enhance selectivity. In complexes which require a high binding flexibility a small number of strong bonds seems to be favored compared to a situation with many but weak bonds.
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"abstract": "We present a simple model which allows to investigate equilibrium aspects of\nmolecular recognition between rigid biomolecules on a generic level. Using a\ntwo-stage approach, which consists of a design and a testing step, the role of\ncooperativity and of varying bond strength in molecular recognition is\ninvestigated. Cooperativity is found to enhance selectivity. In complexes which\nrequire a high binding flexibility a small number of strong bonds seems to be\nfavored compared to a situation with many but weak bonds.",
"arxiv_id": "physics/0608234",
"authors": [
"Hans Behringer",
"Andreas Degenhard",
"Friederike Schmid"
],
"categories": [
"physics.bio-ph"
],
"doi": "10.1103/PhysRevLett.97.128101",
"journal_ref": "Phys. Rev. Lett. 97, 128101 (2006)",
"title": "A Coarse-Grained Lattice Model for Molecular Recognition",
"url": "https://arxiv.org/abs/physics/0608234"
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