dorsal/arxiv
View SchemaRegulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity
| Authors | Gabriele Scheler |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0401039 |
| URL | https://arxiv.org/abs/q-bio/0401039 |
| DOI | 10.1016/j.pneurobio.2004.03.008 |
| Journal | Progress in Neurobiology 72(6), pp 399-415, April 2004 |
Abstract
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental factors, its functional consequences and modes of action are not well understood. In this paper we summarize relevant experimental evidence on NM receptor regulation (specifically dopamine D1 and D2 receptors) in order to explore its significance for neural and synaptic plasticity. We identify the relevant components of NM receptor regulation (receptor phosphorylation, receptor trafficking and sensitization of second-messenger pathways) gained from studies on cultured cells. Key principles in the regulation and control of short-term plasticity (sensitization) are identified, and a model is presented which employs direct and indirect feedback regulation of receptor efficacy. We also discuss long-term plasticity which involves shifts in receptor sensitivity and loss of responsivity to NM signals. Finally, we discuss the implications of NM receptor regulation for models of brain plasticity and memorization. We emphasize that a realistic model of brain plasticity will have to go beyond Hebbian models of long-term potentiation and depression. Plasticity in the distribution and efficacy of NM receptors may provide another important source of functional plasticity with implications for learning and memory.
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"abstract": "Membrane receptors for neuromodulators (NM) are highly regulated in their\ndistribution and efficacy - a phenomenon which influences the individual cell\u0027s\nresponse to central signals of NM release. Even though NM receptor regulation\nis implicated in the pharmacological action of many drugs, and is also known to\nbe influenced by various environmental factors, its functional consequences and\nmodes of action are not well understood. In this paper we summarize relevant\nexperimental evidence on NM receptor regulation (specifically dopamine D1 and\nD2 receptors) in order to explore its significance for neural and synaptic\nplasticity. We identify the relevant components of NM receptor regulation\n(receptor phosphorylation, receptor trafficking and sensitization of\nsecond-messenger pathways) gained from studies on cultured cells. Key\nprinciples in the regulation and control of short-term plasticity\n(sensitization) are identified, and a model is presented which employs direct\nand indirect feedback regulation of receptor efficacy. We also discuss\nlong-term plasticity which involves shifts in receptor sensitivity and loss of\nresponsivity to NM signals. Finally, we discuss the implications of NM receptor\nregulation for models of brain plasticity and memorization. We emphasize that a\nrealistic model of brain plasticity will have to go beyond Hebbian models of\nlong-term potentiation and depression. Plasticity in the distribution and\nefficacy of NM receptors may provide another important source of functional\nplasticity with implications for learning and memory.",
"arxiv_id": "q-bio/0401039",
"authors": [
"Gabriele Scheler"
],
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"doi": "10.1016/j.pneurobio.2004.03.008",
"journal_ref": "Progress in Neurobiology 72(6), pp 399-415, April 2004",
"title": "Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity",
"url": "https://arxiv.org/abs/q-bio/0401039"
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