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As at 30 September 2026
GLOBAL LIFE SCIENCES FUND
H1 GBP ISIN IE00BRJ9D748
Marketing communication - For professional investors only Page 1 / 4
Fund details
Inception date 31 March 2000 Total net assets 5.66bn Asset class Equities Domicile Ireland Structure Irish Investment Company Base currency USD Index MSCI World Health Care Index Morningstar sector Sector Equity Healthcare SFDR category Article 8 This product is based overseas and is not subject to UK sustainable investment labelling and disclosure requirements. In accordance with the Sustainable Finance Disclosure Regulation, the Fund is classified as Article 8 and promotes, among other characteristics, environmental and/or social characteristics, and invests in companies with good governance practices. Share class information
Inception date 20 October 2014 Distribution type Income Distribution frequency Annual Currency GBP Minimum initial investment 2,500
Portfolio management
Andy Acker, CFA Manager since 2007 Daniel Lyons, Ph.D., CFA
Manager since 2023
Ratings
Overall Morningstar Rating TM As of 30/09/2026 Morningstar Medalist Rating TM Effective 27/04/2026 Analyst - Driven%: 100.00 Data Coverage%: 100.00 n/a For more information, refer to page 3 .
Investment objective The Fund aims to provide capital growth over the long term. Performance target: To outperform the MSCI World Health Care Index by at least 2% per annum, before the deduction of charges, over any 5 year period. For the fund’s investment policy, refer to the Additional fund information on page 3 . Past performance does not predict future returns.
Performance (%)
Returns
Cumulative Annualised
1 Month
3 Month YTD
1 Year
3 Year
5 Year
10 Year
Since inception (20/10/14) H1 GBP (Net) - 1.99 - 0.86 9.08 29.24 11.17 8.54 10.81 12.44 Index 0.23 3.23 6.54 17.94 5.93 5.60 8.61 10.24 Sector - 0.04 3.14 4.79 13.72 5.61 1.63 5.94 7.80 H1 GBP (Gross) — — — — — 9.48 11.81 13.47 Target — — — — — 7.72 10.79 12.45
Cumulative growth – GBP
30 Sep 2021 — 30 Sep 2026
━━ Global Life Sciences Fund H1 GBP (Net) ━━ MSCI World Health Care NR ━━ Sector Equity Healthcare - OE
12 month rolling Sep 2025 Sep 2026
Sep 2024 Sep 2025
Sep 2023 Sep 2024
Sep 2022 Sep 2023
Sep 2021 Sep 2022 H1 GBP (Net) 29.24 - 7.45 14.88 3.16 6.24 Index 17.94 - 8.34 9.95 1.41 8.96 Sector 13.72 - 3.46 7.31 - 2.19 - 5.89 Performance is on a net of fees basis, with gross income reinvested. Source: at 30/09/26. © 2026 Morningstar, Inc. All rights reserved. The information contained herein: (1) is proprietary to Morningstar and/or its content providers; (2) may not be copie d or distributed; and (3) is not warranted to be accurate, complete, or timely. Neither Morningstar nor its content providers are responsible for any damages or losses arising from any use of this information. Past performance does not predict future retur ns. Performance/performance target related data will display only where relevant to the share class inception date and annualised target time period. The value of an investment and the income from it can fall as well as rise and you may not get back the am ount originally invested. Source for target returns (where applicable) - Janus Henderson Investors. Please note index returns are net of tax.
-20 -10 0 10 20 30 40 50 60
Sep-21 Sep-22 Sep-23 Sep-24 Sep-25 Sep-26
Page 2
Global Life Sciences Fund H1 GBP (as at 30/09/26)
Page 2 / 4
Top countries (%)
Regions (%)
Codes ISIN IE00BRJ9D748 Bloomberg JGLUGBI Cusip G5S1EE351 SEDOL BRJ9D74 WKN A2H9NE Valoren 25827847 n/a n/a Fees & charges (%) Annual management charge (AMC) 0.80 Ongoing charge (OCF) 0.89 All ongoing charges stated are as per latest published report and accounts. Fund charges will impact the value of your investment. In particular, the ongoing charges applicable to each fund will dilute investment performance, particularly over time. For further explanation of charges please visit our Fund Charges page at www.janushenderson.com. Under some circumstances initial charges may apply. Please refer to the Prospectus for more details.
United States Switzerland United Kingdom Belgium France Denmark Israel Japan South Korea
Fund 82.79 5.41 3.71 2.91 2.00 1.39 1.31 0.31 0.03
Index 74.04 9.00 4.75 1.11 2.04 1.89 0.55 3.37
—
North America Europe United Kingdom Emerging Markets Japan
Fund 82.79 11.71 3.71 1.34 0.31
Index 74.04 16.17 4.75 0.55 3.37
Characteristics Number of holdings: Equity issues 94 Annual turnover (1yr trailing) 28.03% Weighted average market cap 258.49bn Price - to - book ratio 4.98 Price - to - earnings ratio 18.98 n/a n/a Risk statistics (3 years) Fund Index Beta 1.16 — Standard deviation 15.92 12.80 Sharpe ratio 0.39 0.10 Tracking error 6.08 —
Top holdings (%) Fund Eli Lilly 9.61 Johnson & Johnson 7.78 AbbVie 4.93 UnitedHealth Group 4.27 AstraZeneca 3.71 Thermo Fisher Scientific 3.35 Novartis 2.73 Roche 2.68 Argenx 2.45 Merck 2.35 Total 43.86 References made to individual securities do not constitute a recommendation to buy, sell or hold any security, investment strategy or market sector, and should not be assumed to be profitable. Janus Henderson Investors, its affiliated advisor, or its employees, may have a position in the securiti es mentioned.
Market capitalisation of equity holdings (%) Fund Index Over $500B 17.40 18.80 $100B to $500B 40.03 47.53 $50B to $100B 9.16 14.39 $25B to $50B 8.35 14.28 $10B to $25B 7.30 4.58 $5B to $10B 12.17 0.42 $1B to $5B 4.28 — $250M to $1B 1.03 — Under $250M 0.13 —
Sector allocation (%)
Pharmaceuticals Biotechnology Devices and Medical Technology Health Care Services Cash
Fund 34.64 34.43 19.82 10.99 0.13
Index 46.61 18.01 22.88 12.50
—
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Global Life Sciences Fund H1 GBP (as at 30/09/26)
Page 3 / 4
Additional fund information
Tax assumptions and reliefs depend upon an investor’s particular circumstances and may be subject to change. Please note the performance target is to be achieved over a specific annualised time period. Refer to the performance target wording within the obj ective. Please note: due to rounding the figures in the holdings breakdowns may not add up to 100%. This is an Irish Investment Company regulated by the Central Bank of Ireland. Note that any differences among portfolio securities currencies, share class currencies and costs to be paid or represented in currencies other than your home currency will expose you to currency risk. Costs and returns may increase or decrease as a result of currency and exchange ra te fluctuations. To obtain our prospectus and an y additional information please visit our website on: www.janushenderson.com. A short - term trading fee may be applied upon exiting the fund as per the prospectus. Investment into the fund will acquire units/shares of the fund itself and not the und erlying assets owned by the fund. Cash balances and exposures are based on settled and unsettled trades as at the reporting date. Investment policy The Fund invests at least 80% in shares (also known as equities) of companies, of any size, including smaller capitalisation companies, with a life sciences orientation, in any country. Up to 20% may be invested in developing markets. The Fund may also invest in other ass ets including cash and money market instruments. The Sub - Investment Adviser may use derivatives (complex financial instruments) to reduce risk, to manage the Fund more efficiently, or to generate additional capital or income for the Fund. The Fund is actively managed with reference to the MSC I World Health Care Index, which is br oadly representative of the companies in which it may invest, as this forms the basis of the Fund's performance target. The S ub - Investment Adviser has discretion to choose individual investments for the Fund with weightings different to the index or not in the index, but at times the Fund may hold investments similar to the index. Investment strategy The Sub - Investment Adviser looks to identify innovative healthcare companies addressing high unmet medical needs across fields includ ing biotechnology, pharmaceuticals, healthcare services and medical technology. The team understands that success of drug development is binary in nature, creating wide disparities between winners and losers. The investment process leverages proprietary statistical models to analyse the probability of a company's success, focusing on products they believe can overcome the rigours of clinical development. Additional tools, such as physician surveys and prescription models, attempt to more accurately predict commercial viabilit y. Fund specific risks Shares can lose value rapidly, and typically involve higher risks than bonds or money market instruments. The value of your i nvestment may fall as a result. Shares of small and mid - size companies can be more volatile than shares of larger companies, and at times it may be difficult to value or to sell shares at desired times and prices, increasing the risk of losses. High exposure to a particular country or geographical regi on carries a higher level of risk than a more broa dly diversified portfolio. The Fund is focused towards particular industries or investment themes and may be heavily impacted by factors such as changes in government regulation, increased price competition, technological advancements and other adverse eve nts. If the Fund holds assets in currencies other than the base currency of the Fund, or you invest in a share/unit class of a different currency to the Fu nd (unless hedged, i.e. seeks to mitigate exchange rate movements between the share/unit class curren cy and the base currency of the Fund), the value of your investment may be impacted by changes in exchange rates. Derivatives may be used to help achieve the investment objective. This can result in l everage (higher levels of debt), which can magnify an in vestment outcome. Gains or losses may therefore be greater than the cost of the derivative. Derivatives also introduce other risks, in particular, that a derivative counterparty may not meet its contractual obligations. When the Fund, or a shar e/unit class , seeks to mitigate exchange rate movements of a currency relative to the base currency (hedge), the hedging strategy itself may positively or ne gatively impact the value of the Fund due to differences in short - term interest rates between the currencies. S ecurities could become hard to value or to sell at a desired time and price, especially in extreme market conditions when asset prices may be falling, increasing the risk of investment losses. Lo sses could be incurred if a counterparty became unwilling or unable to meet its obligations, or as a result of failure or delay in operational processes or the failure of a third party provider. Source for fund ratings/awards Overall Morningstar Rating™ is a measure of a fund's risk - adjusted return, relative to similar funds. Fund share classes are rated from 1 to 5 stars, with the best performers receiving 5 stars and the worst performers receiving a single star. Where available, overall Morningstar Rating™ is shown for share classes achievin g a rating of 4 or 5 stars. Morningstar Medalist Rating™ Ratings should not be taken as a recommendation. For more detailed information about Morningstar Ratings, including its methodology, please go to https://shareholders.morningstar.com/investor relations/governance/Compliance -- Disclosure/default.aspx .
Glossary
Beta Beta measures how a fund or security moves in relationship to the overall market. A market has a beta of 1. If the fund/security’s beta is more than 1, it moves more than the market, while a beta lower than 1 means it moves to a lesser extent than the market. A negative beta coul d mean the fund/security moves in the opposite direction to the market. Price - to - book (P/B) ratio A financial ratio used to value a company's shares. It is calculated by dividing a company’s market value (share price) by th e book value of its equity (value of the company's assets on its balan ce sheet). A P/B value <1 can indicate a potentially undervalued company or a declining business. The higher the P/B ratio, the higher the premium the market is willing to pay for the company above the book (balance sheet) value of it s assets. Price - to - ea rnings (P/E) ratio A popular ratio used to value a company’s shares, compared to other stocks, or a benchmark index. It is calculated by dividin g the current share price by its earnings per share. Sharpe ratio This measures a portfolio's risk - adjusted per formance. A high Sharpe ratio indicates a better risk - adjusted return. The ratio is designed to measure how far a portfolio’s return can be attributed to fund manager skill as opposed to excessive risk taking. Standard deviation A statistic that measures the variation or dispersion of a set of values/data. A low standard deviation shows the values tend to be close to the mean w hile a high standard deviation indicates the values are more spread out. In terms of valuing investments, standard deviation can p r ovide a gauge of the historical volatility of an investment. Tracking error This measures how far a portfolio’s actual performance differs from its benchmark index. The lower the number, the more close ly it resembles the index. Weighted average market ca p The average market capitalisation of a holding, weighted by the size of that position in a portfolio or index.
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Global Life Sciences Fund H1 GBP (as at 30/09/26)
Page 4 / 4
FOR MORE INFORMATION PLEASE VISIT JANUSHENDERSON.COM
UK investors please note: This product is not authorised in the United Kingdom but overseas; therefore the Financial Ombudsma n Service is unlikely to consider complaints related to the scheme, its operator or its depositary. Any claims for losses relating to the operator and the depositary of the scheme are unlikely to be covered under the compensation scheme and prospective investors should consider getting financial advice b efore deciding to invest. Please read the prospectus of the scheme for more inform ation. For Qualified investors, institutional, wholesale client use only. Outside of Switzerland, this document is for Institutional/sophisticated investors / accredited investors qualified distributors use only. Issued in: (a) Europe by Janus Henderson I nvestors International Limited (“JHIIL”) and Janus Henderson Investors UK Limited (“JHIUKL”), both authorised and regulated i n the U.K by the Financial Conduct Authority, and Janus Henderson Investors Europe S.A. (reg no. B22848) incorporated and registere d in Luxembourg with registered office at 78, Avenue de la Liberté, L - 1930 Luxembourg, Luxembourg and authorised by the Commission de Surveillance du Secteur Financier and (b) Middle East issued by Janus Henderson Investors Middle East Limited (DIFC branch ), regulated by the Dubai Financial Services Authority as a Category 4 licensed entity. JHIIL and JHIUKL act as lead investment advisers to Janus Henderson Capital Funds plc (JHCF). Janus Henderson Investo rs US LLC, Janus Henderson Investors Singapore Limi ted, and Kapstream Capital PTY Limited act as sub - adviser to JHIIL and JHIUKL. JHCF is a UCITS established under Irish law, with segregated liability between funds. Investors are warned that they should only make their investments b ased on the most recent Prospectus which contains information about fees, expenses and risks, which is available from all distributors and paying/fac ilities agents, it should be read carefully. This is a marketing communication. Please refer to the prospectus of the UCITS and to the KID before making any final investment decisions. For sustainability related aspects please access Janushenderson.com. The Prospectus and KID are also available fro m www.janushenderson.com Portfolio Holdings are subject to change without notice. An inv estment in the fund may not be suitable for all investors and is not available to all investors in all jurisdictions; it is not available to US persons. This document is not for use in any c ountry or with any individuals who are not eligible to invest in t his Fund. With effect from 1 January 2023, the Key Investor Information document (KIID) changed to the Key Information Document (KID), except in the UK where investors should continue to refer to the KIID. JHCF is not regulated by the Financial Conduct Aut hority and the protections available under the Financial Services Compensation Scheme and the Financial Ombudsman Service will not be availa ble in connection with an investment. Past performance does not predict future returns. The rate of return may vary and the principal value of an investment will fluctuate due to market and foreign exchange movements. Shares, if redeemed, may be worth more or less than their original cost. This document is provided for information purposes only and is not an invitation to purchase any JHCF Funds. Janus Henderson Group Ltd. and its subsidiaries are not responsible for any unlawful distribution of this document to any third parties, in whole or in part, or for information reconstructed from t his presentation and do not gua rantee that the information supplied is accurate, complete, or timely, or make any warranties with regards to the results obt ained from its use. The performance data does not take into account the commissions and costs incurred on the issue and the redempt ion of shares. This communication does not constitute an offer or a recommendation to sell or purchase any investment.Its custodian is JP Morgan Bank (Ireland) Plc. The last share prices can be found on www.fundinfo.com. Copies of the Fund’s prospectus, Ke y Information Document, articles of incorporation, annual and semi - annual reports are available in English and other local languages as required from www.janushenderson.com. These documents can also be obtai ned free of cost from the local offices of Janus Henderson Investors: 201 Bishopsgate, London, EC2M 3AE for UK. The summary of Investors Rights is available in English from https://www.janushenderson.com/summary - of - investors - rights - english. Janus Henderson Investors Europe S.A.may decide to terminate the marketing arrangements of this Collective Investment Scheme in accordance with the appropriate regulation. Not for onward dis tribution. We may record telephone calls for our mutual protection, to improve customer service and for regulatory record keeping purposes. Janus Henderson® and any other trademarks used herein are trademarks of Janus Henderson Group Ltd. or one of its subsidiaries. © Janus Henderson Group Ltd.
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