{
  "annotation_id": "7874215c-54e7-4506-97e3-9b6d00d11713",
  "date_created": "2026-03-02T18:01:32.290000Z",
  "date_modified": "2026-03-02T18:01:32.290000Z",
  "file_hash": "e2c536e1f90d13c30711ff3770c7cafd591df1a208f08e75f4d661f3ba88b36d",
  "private": false,
  "record": {
    "abstract": "Recent work has shown that expression level is the main predictor of a\ngene\u0026#8217;s evolutionary rate, and that more highly expressed genes evolve\nslower. A possible explanation for this observation is selection for proteins\nwhich fold properly despite mistranslation, in short selection for\ntranslational robustness. Translational robustness leads to the somewhat\nparadoxical prediction that highly expressed genes are extremely tolerant to\nmissense substitutions but nevertheless evolve very slowly. Here, we study a\nsimple theoretical model of translational robustness that allows us to gain\nanalytic insight into how this paradoxical behavior arises.",
    "arxiv_id": "q-bio/0509031",
    "authors": [
      "Claus O. Wilke",
      "D. Allan Drummond"
    ],
    "categories": [
      "q-bio.PE",
      "q-bio.BM",
      "q-bio.GN"
    ],
    "title": "Population genetics of translational robustness",
    "url": "https://arxiv.org/abs/q-bio/0509031"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "97158cfc-4751-4751-bb38-3ec89bdd5f4b",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}