dorsal/arxiv
View SchemaLocal driving and global interactions in the progression of seizure dynamics
| Authors | Benjamin H. Singer, Miron Derchansky, Peter L. Carlen, Michal Zochowski |
|---|---|
| Categories | |
| ArXiv ID | physics/0504212 |
| URL | https://arxiv.org/abs/physics/0504212 |
Abstract
The dynamics underlying epileptic seizures are well understood. We present a novel analysis of seizure-like events (SLEs) in an \textit{ex vivo} whole hippocampus, as well as a modeling study that sheds light on the underlying network dynamics. We show that every SLE can be divided into two phases. During the first, SLE dynamics are driven by the intra-network interaction of a network exhibiting high internal synchrony. The second phase is characterized by lead switching, with the leading region exhibiting low internal synchrony. We show that the second phase dynamics are driven by inter-network feedback among multiple regions of the hippocampus.
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"date_created": "2026-03-02T18:00:57.179000Z",
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"abstract": "The dynamics underlying epileptic seizures are well understood. We present a\nnovel analysis of seizure-like events (SLEs) in an \\textit{ex vivo} whole\nhippocampus, as well as a modeling study that sheds light on the underlying\nnetwork dynamics. We show that every SLE can be divided into two phases. During\nthe first, SLE dynamics are driven by the intra-network interaction of a\nnetwork exhibiting high internal synchrony. The second phase is characterized\nby lead switching, with the leading region exhibiting low internal synchrony.\nWe show that the second phase dynamics are driven by inter-network feedback\namong multiple regions of the hippocampus.",
"arxiv_id": "physics/0504212",
"authors": [
"Benjamin H. Singer",
"Miron Derchansky",
"Peter L. Carlen",
"Michal Zochowski"
],
"categories": [
"physics.bio-ph",
"physics.med-ph"
],
"title": "Local driving and global interactions in the progression of seizure dynamics",
"url": "https://arxiv.org/abs/physics/0504212"
},
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"variant": "snapshot-2026-03-01",
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