dorsal/arxiv
View SchemaDNA looping and physical constraints on transcription regulation
| Authors | Jose M. G. Vilar, Stanislas Leibler |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0411027 |
| URL | https://arxiv.org/abs/q-bio/0411027 |
| Journal | J. Mol. Biol. 331, 981-989 (2003) |
Abstract
DNA looping participates in transcriptional regulation, for instance, by allowing distal binding sites to act synergistically. Here we study this process and compare different regulatory mechanisms based on repression with and without looping. Within a simple mathematical model for the lac operon, we show that regulation based on DNA looping, in addition to increasing the repression level, can reduce the fluctuations of transcription and, at the same time, decrease the sensitivity to changes in the number of regulatory proteins. Looping is thus able to circumvent some of the constraints inherent to mechanisms based solely on binding to a single operator site and provides a mechanism to regulate not only the average properties of transcription but also its fluctuations.
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"abstract": "DNA looping participates in transcriptional regulation, for instance, by\nallowing distal binding sites to act synergistically. Here we study this\nprocess and compare different regulatory mechanisms based on repression with\nand without looping. Within a simple mathematical model for the lac operon, we\nshow that regulation based on DNA looping, in addition to increasing the\nrepression level, can reduce the fluctuations of transcription and, at the same\ntime, decrease the sensitivity to changes in the number of regulatory proteins.\nLooping is thus able to circumvent some of the constraints inherent to\nmechanisms based solely on binding to a single operator site and provides a\nmechanism to regulate not only the average properties of transcription but also\nits fluctuations.",
"arxiv_id": "q-bio/0411027",
"authors": [
"Jose M. G. Vilar",
"Stanislas Leibler"
],
"categories": [
"q-bio.SC",
"cond-mat.soft",
"cond-mat.stat-mech",
"physics.bio-ph"
],
"journal_ref": "J. Mol. Biol. 331, 981-989 (2003)",
"title": "DNA looping and physical constraints on transcription regulation",
"url": "https://arxiv.org/abs/q-bio/0411027"
},
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