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‡ Synthetic Risk and Reward Indicator This document is directed at professional investors and should not be distributed to, or relied upon by retail investors.
Vanguard ®
This is a marketing communication. Factsheet | 30 September 2026
Vanguard U.S. Opportunities Fund
GBP Investor Dist Shares Inception date: 19 December 2006 Total assets (million) £1,071 | Share class assets (million) £25 as at 30 September 2026
Effective 3 March 2014 for the Vanguard U.S. Opportunities fund and from 19 June 2020 for other sub funds and share classes, the products denoted by ‘Closed’ are closed to new accounts; existing shareholders can still make additional share purchases.
Minimum initial investment ISIN SEDOL Bloomberg
Investment structure SRRI ‡ Index ticker Domicile Settlement
Trading frequency (cut-off) £100,000 IE00B1GHC616 B1GHC61 VANGUOG UCITS 6 RAYNP Ireland T+2 Daily (16:00 Irish Time)
Ongoing Charges Figure † 0.95 % †The Ongoing Charges Figure (OCF) covers administration, audit, depository, legal, registration and regulatory expenses incurred in respect of th e Funds. Objectives and investment policy • The Fund seeks to provide long-term capital growth. • The Fund employs an “active management” strategy to invest mainly in U.S. stocks, with an emphasis on companies that are considered to have pros pects for rapid earnings growth. The Fund’s Sub-Investment Manager, PRIMECAP Management Company (“PRIMECAP”), uses fundamental research to identify stocks that are expected to outperform the market over a three to five-year time horizon and that are available at attractive prices relative to their fundamental values. The Fund has the flexibility to invest in companies of any size, but it mostly invests in small and mid-cap stocks. • The Fund may measure performance against the Russell 3000 Index (the “Index”), a market-capitalisation-weighted stock market index, composed o f the top 3,000 US publically traded companies, as ranked by market capitalisation, or the total dollar value of all outstanding shares. The Fund is not otherwise constrained by or managed with reference to the Index. The Index does not define the investment universe of the Fund and the composition of the Fund may deviate significantly from that of the Index. • The Fund’s policy is to remain substantially invested in common stocks that are listed or traded on exchanges or markets in the United States.
Investment manager Investment manager: Vanguard Global Advisers, LLC Sub-investment manager: PRIMECAP Management Company
Page 2
Vanguard U.S. Opportunities Fund
GBP Investor Dist Shares
Performance summary GBP — Vanguard U.S. Opportunities Fund Benchmark — Russell 3000 Index
01 Oct 2016 30 Sep 2017
01 Oct 2017 30 Sep 2018
01 Oct 2018 30 Sep 2019
01 Oct 2019 30 Sep 2020
01 Oct 2020 30 Sep 2021
01 Oct 2021 30 Sep 2022
01 Oct 2022 30 Sep 2023
01 Oct 2023 30 Sep 2024
01 Oct 2024 30 Sep 2025
01 Oct 2025 30 Sep 2026 Fund (Net of expenses) 19.48% 30.51% -5.70% 6.65% 29.14% -4.34% 11.59% 9.20% 22.82% 37.76% Benchmark 14.28% 20.33% 8.29% 9.03% 25.92% -0.94% 9.64% 22.50% 16.54% 16.27%
Annualised performance** 1 month Quarter Year to date 1 year 3 years 5 years 10 years Since inception Fund (Net of expenses ) 2.74% -5.37% 26.35% 37.76% 22.71% 14.55% 14.86% 15.37% Benchmark 1.17% 1.22% 13.54% 16.27% 18.40% 12.51% 13.93% 12.32% **In this document the performance displayed for the Fund(s) and therefore relative performance to the benchmark index may be impacted by swing pric ing. The NAV of a Fund may swing according to subscription/redemption activity so that transaction costs caused by these cashflows are not borne by the existing holders in a Fund. The benchmark index is not affected by swing pricing and therefore you may see tracking difference between the performance of the Fund and the benchmark. Performance and Data is calculated on closing NAV as at 30 September 2026. Past performance is not a reliable indicator of future results. Figures for periods of less than one year are cumulative returns. All other figures represent average annual returns. Performance figures include the reinvestment of all dividends and any capital gains distributions. The performance data does not take account of the commissions and costs incurred in the issue and redemption of s hares. Basis of fund performance is NAV to NAV. Basis of index performance is total return. All performance is calculated in GBP, net of fees.
Source: Vanguard
Rolling 12-month performance
This document is directed at professional investors and should not be distributed to, or relied upon by retail investors.
Key investment risks The value of equities and equity-related securities can be affected by daily stock market movements. Other influential factors include political, econ omic news, company earnings and significant corporate events. Movements in currency exchange rates can adversely affect the return of your investment. Liquidity risk. Lower liquidity means there are insufficient buyers or sellers to allow the Fund to sell or buy investments readily. Counterparty risk. The insolvency of any institutions providing services such as safekeeping of assets or acting as counterparty to derivatives or oth er instruments, may expose the Fund to financial loss. Please also read the risk factors section in the prospectus and the Key Investor Information Document, both of which are available on the Vanguard web site.
Page 3
Top 10 holdings Micron Technology Inc. 9.8 % Xometry Inc. 5.2 Eli Lilly & Co. 4.0 Flex Ltd. 4.0 Intel Corp. 3.1 Alphabet Inc. 2.8 GRAIL Inc. 2.5 BeOne Medicines Ltd. 1.9 Glaukos Corp. 1.7 Nextpower Inc. 1.7 Top 10 approximately equals 36.7% of net assets Data as at 30 September 2026.
Characteristics Fund Benchmark Number of stocks 211 2,996 Median market cap £28.7B £278.8B Price/earnings ratio 24.0x 24.0x Price/book ratio 4.7x 4.8x Return on equity 13.1% 26.3% Earnings growth rate 19.3% 23.5% Turnover rate 5% — Equity yield (dividend) 0.4% 1.1% The PTR (Portfolio Turnover Rate) approach considers the total security purchases and sales, the total subscriptions and redemptions and the average net assets of the fund to calculate the turnover figure. Data as at 30 September 2026.
Energy 1.8 % Consumer Staples 1.7 Materials 1.7 Real Estate 0.2
Information Technology 34.6 % Health Care 24.1 Industrials 17.7 Financials 7.1 Consumer Discretionary 6.4 Communication Services 4.6
Weighted exposureI eInformation Technology
Source: Vanguard
United States 93.0 % China 3.4 United Kingdom 1.5 Canada 1.0 Germany 0.3
Sweden 0.3 % Switzerland 0.2 France 0.1 Japan 0.1 Other 0.0
Vanguard U.S. Opportunities Fund
GBP Investor Dist Shares Data as at 30 September 2026 unless otherwise stated.
This document is directed at professional investors and should not be distributed to, or relied upon by retail investors.
Market allocation
Glossary for fund characteristics The fund characteristics section above contains a number of metrics that professional investors use to value individual stocks against a market or ind ex average. These metrics can also be used to value and compare funds to the market by taking the average of all the stocks held in the fund and comparing them to those of the fund ’s benchmark index. We’ve provided a definition of the terms used for your convenience. Median market cap (capitalisation) looks at all companies in a mutual fund portfolio and calculates the mid point market capitalisation. Market capitalisation represents the aggregate value of a company’s stock. Price earnings ratio (P/E ratio) of a stock is the price paid for a share divided by the annual profit earned by the firm per share. A stock with a price of £10 a share, and earni ngs last year of £1 a share, would have a P/E ratio of 10. Price book ratio compares a stock’s market value to its book value (the accounting value of a stock). It is calculated by dividing the current closing price of t he stock by the latest quarter’s book value per share. Return on equity is a measure of a company’s profitability that reveals how much profit a company generates with the money shareholders have invested. Earnings growth rate is a measure of growth in a company’s net income (what remains after subtracting all the costs from a company’s revenues) over a specific per iod (often one year). Earnings growth can apply to previous periods or estimated data for future periods. Turnover rate is the total value of sales and purchases of stocks by a fund, less any subscriptions and redemptions monies into or out of a fund, expressed as a pe rcentage of the fund’s average value, over a specified period (usually one year). Equity yield characteristics reflects distributions declared over the past twelve months as a percentage of the mid-market unit price, as at the date shown. It does not include a ny preliminary charge and investors may be subject to tax on their distributions.
Sector categories are based on the Global Industry Classification Standard system (”GICS”), except for the ”Other” category (if applica ble), which includes securities that have not been provided a GICS classification as of the effective reporting period.
Page 4
Vanguard U.S. Opportunities Fund
GBP Investor Dist Shares
9122EN_092026 Issued by Vanguard Asset Management, Limited which is authorised and regulated in the UK by the Financial Conduct Authority. © 2026 Vanguard Asset Management, Limited. All rights reserved.
For more information contact your local sales team or: Web: http://global.vanguard.com Transfer Agent (Europe): Tel. +353 1 241 7144 Client Services (Europe): Tel. +44 (0)203 753 4305 Email: european_client_services@vanguard.co.uk Important information This is a marketing communication. This document is directed at professional investors and should not be distributed to, or relied upon by retail investors. For further information on the fund's investment policies and risks, please refer to the prospectus of the UCITS and to the KIID before making any fin al investment decisions. The KIID for this fund is available, alongside the prospectus via Vanguard’s website https://global.vanguard.com/. This document is designed for use by and is directed only at persons resident in the UK. The information contained herein is not to be regarded as an offer to buy or sell or the solicitation of any offer to buy or sell securities in any ju risdiction where such an offer or solicitation is against the law, or to anyone to whom it is unlawful to make such an offer or solicitation, or if the person making the offer or solic itation is not qualified to do so. The information in this document is general in nature and does not constitute legal, tax, or investment advice. Potential investors are urged to consult t heir professional advisers on the implications of making an investment in, holding or disposing of ''units/shares'', and the receipt of distribution from any investment. Vanguard Investment Series plc has been authorised by the Central Bank of Ireland as a UCITS and has been registered for public distribution in certain EEA countries and the UK. Prospective investors are referred to the Funds' prospectus for further information. Prospective investors are also urged to consult their own profess ional advisers on the implications of making an investment in, and holding or disposing shares of the Funds and the receipt of distributions with respect to such shares und er the law of the countries in which they are liable to taxation. The Manager of Vanguard Investment Series plc is Vanguard Group (Ireland) Limited. Vanguard Asset Management, Limited is a distributor of Vanguar d Investment Series plc. The Manager of the Ireland-domiciled funds may determine to terminate any arrangements made for marketing the shares in one or more jurisdictions in a ccordance with the UCITS Directive, as may be amended from time to time. For investors in Ireland-domiciled funds, a summary of investor rights can be obtained via https://www.ie.vanguard/content/dam/intl/europe/documents/en/vanguard-investors-rights-summary-irish-funds-jan22.pdf and is available in English, Ge rman, French, Spanish, Dutch and Italian. London Stock Exchange Group plc and its group undertakings (collectively, the “LSE Group”). © LSE Group. FTSE Russell is a trading name of certain of the LSE Group companies. e.g., “FTSE®” “Russell®”, “FTSE Russell®”, “FTSE4Good®”, “ICB®”, “Mergent®, The Yield Book®,” is/are a trade mark(s) of the relevant LSE Group companies and is/are used by any other LSE Group company under license. All rights in the FTSE Russell indexes or data vest in the relevant LSE Group company which owns the index or t he data. Neither LSE Group nor its licensors accept any liability for any errors or omissions in the indexes or data and no party may rely on any indexes or data contained in th is communication. No further distribution of data from the LSE Group is permitted without the relevant LSE Group company’s express written consent. The LSE Group does not promo te, sponsor or endorse the content of this communication. SEDOL and SEDOL Masterfile® are registered trademarks of the London Stock Exchange Group PLC. SEDOL Data has been provided from the London Stock Exchange’s SEDOL Masterfile®.
Investment risk information The value of investments, and the income from them, may fall or rise and investors may get back less than they invested. Past performance is not a reliable indicator of future results. Investments in smaller companies may be more volatile than investments in well-established blue chip companies. The Funds may use derivatives in order to reduce risk or cost and/or generate extra income or growth. The use of derivatives could increase or reduce exposure to underlying assets and result in greater fluctuations of the Fund’s net asset value. A derivative is a financial contract whose value is based on the value of a financial asset (such as a share, bond, or currency) or a market index. Some funds invest in securities which are denominated in different currencies. Movements in currency exchange rates can affect the return of investmen ts. For further information on risks, please see the ’Risk Factors’ section of the prospectus on our website at https://global.vanguard.com.
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