{
  "annotation_id": "73367af7-3f60-4f87-a3de-bfb1a7ba101b",
  "date_created": "2026-03-02T18:01:21.582000Z",
  "date_modified": "2026-03-02T18:01:21.582000Z",
  "file_hash": "ed9c8f27084ec69e7e0fb2f6741642fda1d32e8b5ea185e6c661314f101e6ba8",
  "private": false,
  "record": {
    "abstract": "A system containing a pre-steady state standard (non-autocatalytic) reaction,\nwith multiple paths, evolves toward a kinetic state with the minimum attainable\nactivation free energy. Displacement of the path frequency distribution in this\ntransition was shown to minimise the affinity linked to this change in\nactivation free energy. In damping this scalar force, a standard system is\ndriven along a path of least action, as previously established for a system of\ncompeting autocatalytic reactions. A kinetic source of time asymmetry arises\nwithin the system, as the activation affinity moves the system toward the most\nprobable distribution of reaction paths. As the functions of state are not\nchanged by path displacement, a change of kinetic state cannot produce chemical\nwork. This generalises the notion of force to a scalar quantity responsible for\na displacement that does not yield work or heat. Spectrophotometric\nobservations reported on the transition to steady state kinetics during\ndinitrophenyl phosphate phosphorolysis confirmed that time variations in the\nactivation affinity are non-positive.",
    "arxiv_id": "physics/9704027",
    "authors": [
      "Brian K. Davis"
    ],
    "categories": [
      "physics.chem-ph"
    ],
    "title": "Transition to the Most Probable Kinetic State in a Pre-Steady State   System",
    "url": "https://arxiv.org/abs/physics/9704027"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "1d6f3891-2342-4173-8c69-6b9800add398",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}