{
  "annotation_id": "72976ddb-c525-469f-9405-17ce86e9879a",
  "date_created": "2026-03-02T18:01:35.363000Z",
  "date_modified": "2026-03-02T18:01:35.363000Z",
  "file_hash": "116ffc8c4a2dcba74a9a96c1ffc1b380c8957a5949534a1d440d997f4a37758f",
  "private": false,
  "record": {
    "abstract": "Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue\nIn obesity, adipocyte hypertrophy is often associated with recrutement of new\nfat cells (adipogenesis) under the control of circulating and local regulatory\nfactors. Among the different lipids released in the extracellular compartment\nof adipocytes, our group found the presence of lysophosphatidic acid (LPA). LPA\nis a bioactive phospholipid able to regulate several cell responses via the\nactivation of specific G-protein coupled membrane receptors. Our group found\nthat LPA increases preadipocyte proliferation and inhibits adipogenesis via the\nactivation of LPA1 receptor subtype. Extracellular LPA-synthesis is catalyzed\nby a lysophospholipase D secreted by adipocytes : autotaxin (ATX). Adipocyte\nATX expression strongly increases with adipogenesis as well as in individuals\nexhibiting type 2 diabetes associated with massive obesity. A possible\ncontribution of ATX and LPA as paracrine regulators of adipogenesis and obesity\nassociated diabetes is proposed.",
    "arxiv_id": "q-bio/0610049",
    "authors": [
      "Jean S\u00e9bastien Saulnier-Blache"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "title": "Contr\\^{o}le paracrine du d\\\u0027{e}veloppement du tissu adipeux par   l\u0027autotaxine et l\u0027acide lysophosphatidique",
    "url": "https://arxiv.org/abs/q-bio/0610049"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a04e1dd5-1d70-46e9-afb8-c488572ada8a",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}