dorsal/arxiv
View SchemaModel for Osteosarcoma-9 as a Potent Factor in Cell Survivor and Resistance to Apoptosis
| Authors | Ekaterini Vourvouhaki, Carla Carvalho, Paulo Aguiar |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0608030 |
| URL | https://arxiv.org/abs/q-bio/0608030 |
| DOI | 10.1103/PhysRevE.76.011926 |
| Journal | Phys. Rev. E 76, 011926 (2007) |
Abstract
In this paper we use a simple toy model to explore the function of the gene Osteosarcoma-9. We are in particular interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest that OS-9 promotes cell viability and confers resistance to apoptosis, potentially implicating OS-9 in the survival of cancer cells. Three different apoptosis inducing mechanisms were tested and are here modelled. More complex and realistic models are also discussed.
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"abstract": "In this paper we use a simple toy model to explore the function of the gene\nOsteosarcoma-9. We are in particular interested in understanding the role of\nthis gene as a potent anti-apoptotic factor. The theoretical description is\nconstrained by experimental data from induction of apoptosis in cells where\nOS-9 is overexpressed. The data available suggest that OS-9 promotes cell\nviability and confers resistance to apoptosis, potentially implicating OS-9 in\nthe survival of cancer cells. Three different apoptosis inducing mechanisms\nwere tested and are here modelled. More complex and realistic models are also\ndiscussed.",
"arxiv_id": "q-bio/0608030",
"authors": [
"Ekaterini Vourvouhaki",
"Carla Carvalho",
"Paulo Aguiar"
],
"categories": [
"q-bio.SC"
],
"doi": "10.1103/PhysRevE.76.011926",
"journal_ref": "Phys. Rev. E 76, 011926 (2007)",
"title": "Model for Osteosarcoma-9 as a Potent Factor in Cell Survivor and Resistance to Apoptosis",
"url": "https://arxiv.org/abs/q-bio/0608030"
},
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