{
  "annotation_id": "71396588-d7d6-4a78-bbf0-0af0a6f0c36a",
  "date_created": "2026-03-02T18:01:24.890000Z",
  "date_modified": "2026-03-02T18:01:24.890000Z",
  "file_hash": "c93d8e692891b946f2c6b538045a769630b6434b776c11cd78fc87f0599ca583",
  "private": false,
  "record": {
    "abstract": "We have micromachined a silicon-chip device that transports DNA with a\nBrownian ratchet that rectifies the Brownian motion of microscopic particles.\nTransport properties for a DNA 50mer agree with theoretical predictions, and\nthe DNA diffusion constant agrees with previous experiments. This type of\nmicromachine could provide a generic pump or separation component for DNA or\nother charged species as part of a microscale lab-on-a-chip. A device with\nreduced feature size could produce a size-based separation of DNA molecules,\nwith applications including the detection of single nucleotide polymorphisms.",
    "arxiv_id": "physics/9912043",
    "authors": [
      "Joel S. Bader",
      "Richard W. Hammond",
      "Steven A. Henck",
      "Michael W. Deem",
      "Gregory A. McDermott",
      "James M. Bustillo",
      "John W. Simpson",
      "Gregory T. Mulhern",
      "Jonathan M. Rothberg"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.soft",
      "q-bio"
    ],
    "doi": "10.1073/pnas.96.23.13165",
    "journal_ref": "Proc. Natl. Acad. Sci. USA 96(23): 13165-13169 (1999)",
    "title": "DNA transport by a micromachined Brownian ratchet device",
    "url": "https://arxiv.org/abs/physics/9912043"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "b8154fc1-876d-425d-b44a-de1217648126",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}