dorsal/arxiv
View SchemaEpitope analysis for influenza vaccine design
| Authors | Enrique T. Munoz, Michael W. Deem |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0408016 |
| URL | https://arxiv.org/abs/q-bio/0408016 |
Abstract
Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune response that results from antigenic drift in the epitopes of the hemagglutinin and neuraminidase proteins. The results explain the ineffectiveness of the 2003--2004 influenza vaccine in the United States and provide an accurate measure by which to optimize the effectiveness of future annual influenza vaccines.
{
"annotation_id": "6f63f042-9d84-4383-8193-56964bf6e15e",
"date_created": "2026-03-02T18:01:32.283000Z",
"date_modified": "2026-03-02T18:01:32.283000Z",
"file_hash": "ff229715f836c22aa1f387517731a57a0b773b5d3f471e6866b86e249c5d23a1",
"private": false,
"record": {
"abstract": "Until now, design of the annual influenza vaccine has relied on phylogenetic\nor whole-sequence comparisons of the viral coat proteins hemagglutinin and\nneuraminidase, with vaccine effectiveness assumed to correlate monotonically to\nthe vaccine-influenza sequence difference. We use a theory from statistical\nmechanics to quantify the non-monotonic immune response that results from\nantigenic drift in the epitopes of the hemagglutinin and neuraminidase\nproteins. The results explain the ineffectiveness of the 2003--2004 influenza\nvaccine in the United States and provide an accurate measure by which to\noptimize the effectiveness of future annual influenza vaccines.",
"arxiv_id": "q-bio/0408016",
"authors": [
"Enrique T. Munoz",
"Michael W. Deem"
],
"categories": [
"q-bio.BM",
"q-bio.QM"
],
"title": "Epitope analysis for influenza vaccine design",
"url": "https://arxiv.org/abs/q-bio/0408016"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "3a5d6ca2-820e-4628-a85e-0b59f8c7dde9",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}