dorsal/arxiv
View SchemaAlternative mechanisms of structuring biomembranes: Self-assembly vs. self-organization
| Authors | Karin John, Markus Baer |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0506033 |
| URL | https://arxiv.org/abs/q-bio/0506033 |
| DOI | 10.1103/PhysRevLett.95.198101 |
| Journal | Phys. Rev. Lett. 96 (2005) 198101 |
Abstract
We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self-assembly of protein domains by electrostatic lipid-protein interactions is contrasted with self-organization due to a nonequilibrium biochemical reaction cycle of proteins near the membrane. While both processes lead eventually to quite similar patterns, their evolution occurs on very different length and time scales. Self-assembly produces periodic protein patterns on a spatial scale below 0.1 micron in a few seconds followed by extremely slow coarsening, whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 micron within a few minutes suggesting different biological functions for the two processes.
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"abstract": "We study two mechanisms for the formation of protein patterns near membranes\nof living cells by mathematical modelling. Self-assembly of protein domains by\nelectrostatic lipid-protein interactions is contrasted with self-organization\ndue to a nonequilibrium biochemical reaction cycle of proteins near the\nmembrane. While both processes lead eventually to quite similar patterns, their\nevolution occurs on very different length and time scales. Self-assembly\nproduces periodic protein patterns on a spatial scale below 0.1 micron in a few\nseconds followed by extremely slow coarsening, whereas self-organization\nresults in a pattern wavelength comparable to the typical cell size of 100\nmicron within a few minutes suggesting different biological functions for the\ntwo processes.",
"arxiv_id": "q-bio/0506033",
"authors": [
"Karin John",
"Markus Baer"
],
"categories": [
"q-bio.CB",
"nlin.PS",
"physics.bio-ph"
],
"doi": "10.1103/PhysRevLett.95.198101",
"journal_ref": "Phys. Rev. Lett. 96 (2005) 198101",
"title": "Alternative mechanisms of structuring biomembranes: Self-assembly vs. self-organization",
"url": "https://arxiv.org/abs/q-bio/0506033"
},
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