dorsal/arxiv
View SchemaCable dynamics applied to long-length scale mechanics of DNA
| Authors | Sachin Goyal, Todd Lillian, Noel C. Perkins, Edgar Meyhofer |
|---|---|
| Categories | |
| ArXiv ID | physics/0702197 |
| URL | https://arxiv.org/abs/physics/0702197 |
Abstract
This paper introduces the use of cable dynamics models as a means to explore the mechanics of DNA on long-length scales. It is on these length scales that DNA forms twisted and curved three-dimensional shapes known as supercoils and loops. These long-length scale DNA structures have a pronounced influence on the functions of this molecule within the cell including the packing of DNA in the cell nucleus, transcription, replication and gene repair. We provide a short background to the mechanics of DNA and suggest the logical connection to the mechanics of a low tension cable. A computational model is then summarized and example results are presented for DNA supercoiling and looping.
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"abstract": "This paper introduces the use of cable dynamics models as a means to explore\nthe mechanics of DNA on long-length scales. It is on these length scales that\nDNA forms twisted and curved three-dimensional shapes known as supercoils and\nloops. These long-length scale DNA structures have a pronounced influence on\nthe functions of this molecule within the cell including the packing of DNA in\nthe cell nucleus, transcription, replication and gene repair. We provide a\nshort background to the mechanics of DNA and suggest the logical connection to\nthe mechanics of a low tension cable. A computational model is then summarized\nand example results are presented for DNA supercoiling and looping.",
"arxiv_id": "physics/0702197",
"authors": [
"Sachin Goyal",
"Todd Lillian",
"Noel C. Perkins",
"Edgar Meyhofer"
],
"categories": [
"physics.bio-ph",
"physics.chem-ph",
"physics.comp-ph"
],
"title": "Cable dynamics applied to long-length scale mechanics of DNA",
"url": "https://arxiv.org/abs/physics/0702197"
},
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