dorsal/arxiv
View SchemaDo reductionist cures select for holistic diseases? Adaptive chronic infection, structured stress, and medical magic bullets
| Authors | Rodrick Wallace, Robert G. Wallace |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0311005 |
| URL | https://arxiv.org/abs/q-bio/0311005 |
Abstract
With a generalized language-of-thought argument for immune cognition, we model how population-directed structured psychosocial stress can impose an image of itself on the coevolutionary conflict between a highly adaptive chronic infection and the immune system. We raise the possibility that, for successful 'evolution machines' like HIV and malaria, simplistic individual-oriented magic bullet drug treatments, vaccines, behavior modification, or other interventions that do not address the fundamental living and working conditions underlying disease ecology will fail to control current epidemics and may select for holistic pathogenic life histories which increase disease virulence.
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"date_created": "2026-03-02T18:01:28.752000Z",
"date_modified": "2026-03-02T18:01:28.752000Z",
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"abstract": "With a generalized language-of-thought argument for immune cognition, we\nmodel how population-directed structured psychosocial stress can impose an\nimage of itself on the coevolutionary conflict between a highly adaptive\nchronic infection and the immune system. We raise the possibility that, for\nsuccessful \u0027evolution machines\u0027 like HIV and malaria, simplistic\nindividual-oriented magic bullet drug treatments, vaccines, behavior\nmodification, or other interventions that do not address the fundamental living\nand working conditions underlying disease ecology will fail to control current\nepidemics and may select for holistic pathogenic life histories which increase\ndisease virulence.",
"arxiv_id": "q-bio/0311005",
"authors": [
"Rodrick Wallace",
"Robert G. Wallace"
],
"categories": [
"q-bio.NC",
"q-bio.PE"
],
"title": "Do reductionist cures select for holistic diseases? Adaptive chronic infection, structured stress, and medical magic bullets",
"url": "https://arxiv.org/abs/q-bio/0311005"
},
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"source": {
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"type": "Model",
"variant": "snapshot-2026-03-01",
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