dorsal/arxiv
View SchemaExpression of MHC II genes
| Authors | G. Drozina, J. Kohoutek, N. Jabrane-Ferrat, B. M. Peterlin |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0609017 |
| URL | https://arxiv.org/abs/q-bio/0609017 |
| Journal | Current topics in microbiology and immunology. 290 (2005) Pages 147-70, Accession Number 16480042 |
Abstract
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants. MHC class II (MHC II) determinants present antigens to CD4+ T cells, which are the main regulators of the immune response. Their genes are transcribed from compact promoters that form first the MHC II enhanceosome, which contains DNA-bound activators and then the MHC II transcriptosome with the addition of the class II transactivator (CIITA). CIITA is the master regulator of MHC II transcription. It is expressed constitutively in dendritic cells (DC) and mature B cells and is inducible in most other cell types. Three isoforms of CIITA exist, depending on cell type and inducing signals. CIITA is regulated at the levels of transcription and post-translational modifications, which are still not very clear. Inappropriate immune responses are found in several diseases, including cancer and autoimmunity. Since CIITA regulates the expression of MHC II genes, it is involved directly in the regulation of the immune response. The knowledge of CIITA will facilitate the manipulation of the immune response and might contribute to the treatment of these diseases.
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"abstract": "Innate and adaptive immunity are connected via antigen processing and\npresentation (APP), which results in the presentation of antigenic peptides to\nT cells in the complex with the major histocompatibility (MHC) determinants.\nMHC class II (MHC II) determinants present antigens to CD4+ T cells, which are\nthe main regulators of the immune response. Their genes are transcribed from\ncompact promoters that form first the MHC II enhanceosome, which contains\nDNA-bound activators and then the MHC II transcriptosome with the addition of\nthe class II transactivator (CIITA). CIITA is the master regulator of MHC II\ntranscription. It is expressed constitutively in dendritic cells (DC) and\nmature B cells and is inducible in most other cell types. Three isoforms of\nCIITA exist, depending on cell type and inducing signals. CIITA is regulated at\nthe levels of transcription and post-translational modifications, which are\nstill not very clear. Inappropriate immune responses are found in several\ndiseases, including cancer and autoimmunity. Since CIITA regulates the\nexpression of MHC II genes, it is involved directly in the regulation of the\nimmune response. The knowledge of CIITA will facilitate the manipulation of the\nimmune response and might contribute to the treatment of these diseases.",
"arxiv_id": "q-bio/0609017",
"authors": [
"G. Drozina",
"J. Kohoutek",
"N. Jabrane-Ferrat",
"B. M. Peterlin"
],
"categories": [
"q-bio.GN"
],
"journal_ref": "Current topics in microbiology and immunology. 290 (2005) Pages\n 147-70, Accession Number 16480042",
"title": "Expression of MHC II genes",
"url": "https://arxiv.org/abs/q-bio/0609017"
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