dorsal/arxiv
View SchemaEvolution of the Protein Interaction Network of Budding Yeast: Role of the Protein Family Compatibility Constraint
| Authors | K. -I. Goh, B. Kahng, D. Kim |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0312009 |
| URL | https://arxiv.org/abs/q-bio/0312009 |
| Journal | J. Korean Phys. Soc. 46, 551 (2005) |
Abstract
Understanding of how protein interaction networks (PIN) of living organisms have evolved or are organized can be the first stepping stone in unveiling how life works on a fundamental ground. Here we introduce a hybrid network model composed of the yeast PIN and the protein family interaction network. The essential ingredient of the model includes the protein family identity and its robustness under evolution, as well as the three previously proposed ones: gene duplication, divergence, and mutation. We investigate diverse structural properties of our model with parameter values relevant to yeast, finding that the model successfully reproduces the empirical data.
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"abstract": "Understanding of how protein interaction networks (PIN) of living organisms\nhave evolved or are organized can be the first stepping stone in unveiling how\nlife works on a fundamental ground. Here we introduce a hybrid network model\ncomposed of the yeast PIN and the protein family interaction network. The\nessential ingredient of the model includes the protein family identity and its\nrobustness under evolution, as well as the three previously proposed ones: gene\nduplication, divergence, and mutation. We investigate diverse structural\nproperties of our model with parameter values relevant to yeast, finding that\nthe model successfully reproduces the empirical data.",
"arxiv_id": "q-bio/0312009",
"authors": [
"K. -I. Goh",
"B. Kahng",
"D. Kim"
],
"categories": [
"q-bio.MN",
"cond-mat"
],
"journal_ref": "J. Korean Phys. Soc. 46, 551 (2005)",
"title": "Evolution of the Protein Interaction Network of Budding Yeast: Role of the Protein Family Compatibility Constraint",
"url": "https://arxiv.org/abs/q-bio/0312009"
},
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"type": "Model",
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