dorsal/arxiv
View SchemaMacroscopic consequences of calcium signaling in microdomains: A first passage time approach
| Authors | Robert Rovetti, Kunal K. Das, Alan Garfinkel, Yohannes Shiferaw |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0701043 |
| URL | https://arxiv.org/abs/q-bio/0701043 |
| DOI | 10.1103/PhysRevE.76.051920 |
| Journal | Phys. Rev. E 76, 051920 (2007) |
Abstract
Calcium (Ca) plays an important role in regulating various cellular processes. In a variety of cell types, Ca signaling occurs within microdomains where channels deliver localized pulses of Ca which activate a nearby collection of Ca-sensitive receptors. The small number of channels involved ensures that the signaling process is stochastic. The aggregate response of several thousand of these microdomains yields a whole-cell response which dictates the cell behavior. Here, we study analytically the statistical properties of a population of these microdomains in response to a trigger signal. We apply these results to understand the relationship between Ca influx and Ca release in cardiac cells. In this context, we use a first passage time approach to show analytically how Ca release in the whole cell depends on the single channel kinetics of Ca channels and the properties of microdomains. Using these results, we explain the underlying mechanism for the graded relationship between Ca influx and Ca release in cardiac cells.
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"abstract": "Calcium (Ca) plays an important role in regulating various cellular\nprocesses. In a variety of cell types, Ca signaling occurs within microdomains\nwhere channels deliver localized pulses of Ca which activate a nearby\ncollection of Ca-sensitive receptors. The small number of channels involved\nensures that the signaling process is stochastic. The aggregate response of\nseveral thousand of these microdomains yields a whole-cell response which\ndictates the cell behavior. Here, we study analytically the statistical\nproperties of a population of these microdomains in response to a trigger\nsignal. We apply these results to understand the relationship between Ca influx\nand Ca release in cardiac cells. In this context, we use a first passage time\napproach to show analytically how Ca release in the whole cell depends on the\nsingle channel kinetics of Ca channels and the properties of microdomains.\nUsing these results, we explain the underlying mechanism for the graded\nrelationship between Ca influx and Ca release in cardiac cells.",
"arxiv_id": "q-bio/0701043",
"authors": [
"Robert Rovetti",
"Kunal K. Das",
"Alan Garfinkel",
"Yohannes Shiferaw"
],
"categories": [
"q-bio.SC",
"cond-mat.stat-mech",
"physics.bio-ph"
],
"doi": "10.1103/PhysRevE.76.051920",
"journal_ref": "Phys. Rev. E 76, 051920 (2007)",
"title": "Macroscopic consequences of calcium signaling in microdomains: A first passage time approach",
"url": "https://arxiv.org/abs/q-bio/0701043"
},
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