dorsal/arxiv
View SchemaProbability of fixation of an advantageous mutant in a viral quasispecies
| Authors | Claus O. Wilke |
|---|---|
| Categories | |
| ArXiv ID | physics/0209099 |
| URL | https://arxiv.org/abs/physics/0209099 |
| Journal | Genetics 163:457-466, 2003 |
Abstract
The probability that an advantageous mutant rises to fixation in a viral quasispecies is investigated in the framework of multi-type branching processes. Whether fixation is possible depends on the overall growth rate of the quasispecies that will form if invasion is successful, rather than on the individual fitness of the invading mutant. The exact fixation probability can only be calculated if the fitnesses of all potential members of the invading quasispecies are known. Quasispecies fixation has two important characteristics: First, a sequence with negative selection coefficient has a positive fixation probability as long as it has the potential to grow into a quasispecies with an overall growth rate that exceeds the one of the established quasispecies. Second, the fixation probabilities of sequences with identical fitnesses can nevertheless vary over many orders of magnitudes. Two approximations for the probability of fixation are introduced. Both approximations require only partial knowledge about the potential members of the invading quasispecies. The performance of these two approximations is compared to the exact fixation probability on a network of RNA sequences with identical secondary structure.
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"abstract": "The probability that an advantageous mutant rises to fixation in a viral\nquasispecies is investigated in the framework of multi-type branching\nprocesses. Whether fixation is possible depends on the overall growth rate of\nthe quasispecies that will form if invasion is successful, rather than on the\nindividual fitness of the invading mutant. The exact fixation probability can\nonly be calculated if the fitnesses of all potential members of the invading\nquasispecies are known. Quasispecies fixation has two important\ncharacteristics: First, a sequence with negative selection coefficient has a\npositive fixation probability as long as it has the potential to grow into a\nquasispecies with an overall growth rate that exceeds the one of the\nestablished quasispecies. Second, the fixation probabilities of sequences with\nidentical fitnesses can nevertheless vary over many orders of magnitudes. Two\napproximations for the probability of fixation are introduced. Both\napproximations require only partial knowledge about the potential members of\nthe invading quasispecies. The performance of these two approximations is\ncompared to the exact fixation probability on a network of RNA sequences with\nidentical secondary structure.",
"arxiv_id": "physics/0209099",
"authors": [
"Claus O. Wilke"
],
"categories": [
"physics.bio-ph",
"q-bio.PE"
],
"journal_ref": "Genetics 163:457-466, 2003",
"title": "Probability of fixation of an advantageous mutant in a viral quasispecies",
"url": "https://arxiv.org/abs/physics/0209099"
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