dorsal/arxiv
View SchemaDynamic receptor team formation can explain the high signal transduction gain in E. coli
| Authors | Reka Albert, Yu-wen Chiu, Hans G. Othmer |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0312012 |
| URL | https://arxiv.org/abs/q-bio/0312012 |
| DOI | 10.1016/S0006-3495(04)74321-0 |
| Journal | Biophysical Journal 86, 2650-2659 (2004) |
Abstract
Evolution has provided many organisms with sophisticated sensory systems that enable them to respond to signals in their environment. The response frequently involves alteration in the pattern of movement, such as the chemokinesis of the bacterium Escherichia coli, which swims by rotating its flagella. When rotated counterclockwise (CCW) the flagella coalesce into a propulsive bundle, producing a relatively straight ``run'', and when rotated clockwise (CW) they fly apart, resulting in a ``tumble'' which reorients the cell with little translocation. A stochastic process generates the runs and tumbles, and in a chemoeffector gradient runs that carry the cell in a favorable direction are extended. The overall structure of the signal transduction pathways is well-characterized in E. coli, but important details are still not understood. Only recently has a source of gain in the signal transduction network been identified experimentally, and here we present a mathematical model based on dynamic assembly of receptor teams that can explain this observation.
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"abstract": "Evolution has provided many organisms with sophisticated sensory systems that\nenable them to respond to signals in their environment. The response frequently\ninvolves alteration in the pattern of movement, such as the chemokinesis of the\nbacterium Escherichia coli, which swims by rotating its flagella. When rotated\ncounterclockwise (CCW) the flagella coalesce into a propulsive bundle,\nproducing a relatively straight ``run\u0027\u0027, and when rotated clockwise (CW) they\nfly apart, resulting in a ``tumble\u0027\u0027 which reorients the cell with little\ntranslocation. A stochastic process generates the runs and tumbles, and in a\nchemoeffector gradient runs that carry the cell in a favorable direction are\nextended. The overall structure of the signal transduction pathways is\nwell-characterized in E. coli, but important details are still not understood.\nOnly recently has a source of gain in the signal transduction network been\nidentified experimentally, and here we present a mathematical model based on\ndynamic assembly of receptor teams that can explain this observation.",
"arxiv_id": "q-bio/0312012",
"authors": [
"Reka Albert",
"Yu-wen Chiu",
"Hans G. Othmer"
],
"categories": [
"q-bio.MN",
"q-bio.QM"
],
"doi": "10.1016/S0006-3495(04)74321-0",
"journal_ref": "Biophysical Journal 86, 2650-2659 (2004)",
"title": "Dynamic receptor team formation can explain the high signal transduction gain in E. coli",
"url": "https://arxiv.org/abs/q-bio/0312012"
},
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