{
  "annotation_id": "63e4d8c5-5b2a-4ead-b5ef-5b5fe54fd1f4",
  "date_created": "2026-03-02T18:01:35.011000Z",
  "date_modified": "2026-03-02T18:01:35.011000Z",
  "file_hash": "44a1cdbf2972fc8309331cd7916807999873516ef1fb98e3dc90e002a52e40ca",
  "private": false,
  "record": {
    "abstract": "We present a dynamical model of lipoprotein metabolism derived by combining a\ncascading process in the blood stream and cellular level regulatory dynamics.\nWe analyse the existence and stability of equilibria and show that this\nlow-dimensional, nonlinear model exhibits bistability between a low and a high\ncholesterol state. A sensitivity analysis indicates that the intracellular\nconcentration of cholesterol is robust to parametric variations while the\nplasma cholesterol can vary widely. We show how the dynamical response to\ntime-dependent inputs can be used to diagnose the state of the system. We also\nestablish the connection between parameters in the system and medical and\ngenetic conditions.",
    "arxiv_id": "q-bio/0610053",
    "authors": [
      "Elias August",
      "Kim H. Parker",
      "Mauricio Barahona"
    ],
    "categories": [
      "q-bio.QM",
      "q-bio.CB"
    ],
    "title": "A Dynamical Model of Lipoprotein Metabolism",
    "url": "https://arxiv.org/abs/q-bio/0610053"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "b2443da0-5029-4d51-8a5e-25a519bafc7b",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}